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Toxicology. 2020 Feb 15:431:152365. doi: 10.1016/j.tox.2020.152365 Q14.62025

Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice

全氟辛烷磺酸干扰小鼠肠道菌群-宿主代谢稳态 翻译改进

Limin Zhang  1, Bipin Rimal  2, Robert G Nichols  3, Yuan Tian  3, Philip B Smith  4, Emmanuel Hatzakis  5, Shu-Ching Chang  6, John L Butenhoff  7, Jeffrey M Peters  3, Andrew D Patterson  8

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作者单位

  • 1 Department of Veterinary and Biomedical Science and the Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA, USA; CAS Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Centre for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences (CAS), Wuhan, 430071, China.
  • 2 Department of Veterinary and Biomedical Science and the Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA, USA; The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA.
  • 3 Department of Veterinary and Biomedical Science and the Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA, USA.
  • 4 The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA.
  • 5 Department of Food Science and Technology, The Ohio State University, Columbus, OH, USA.
  • 6 Medical Department, 3M Company, St. Paul, MN, USA.
  • 7 Salutox L.L.C., Lake Elmo, MN, USA.
  • 8 Department of Veterinary and Biomedical Science and the Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA, USA. Electronic address: adp117@psu.edu.

    • DOI: 10.1016/j.tox.2020.152365 PMID: 31926186

    摘要 Ai翻译

    Perfluorooctane sulfonate (PFOS) is a persistent environmental chemical whose biological effects are mediated by multiple mechanisms. Recent evidence suggests that the gut microbiome may be directly impacted by and/or alter the fate and effects of environmental chemicals in the host. Thus, the aim of this study was to determine whether PFOS influences the gut microbiome and its metabolism, and the host metabolome. Four groups of male C57BL/6 J mice were fe... ...点击完成人机验证后继续浏览
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    期刊名：Toxicology

    缩写：TOXICOLOGY

    ISSN：0300-483X

    e-ISSN：1879-3185

    IF/分区：4.6/Q1

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    Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice