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Review Brain research bulletin. 2019 Sep:151:3-11. doi: 10.1016/j.brainresbull.2018.12.013 Q23.52024

Purinergic receptors in neurogenic processes

神经源性过程中的嘌呤能受体 翻译改进

D E Ribeiro  1, T Glaser  1, Á Oliveira-Giacomelli  1, H Ulrich  2

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作者单位

  • 1 Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, 05508-900, Av. Prof. Lineu Prestes, 748, São Paulo, SP, Brazil.
  • 2 Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, 05508-900, Av. Prof. Lineu Prestes, 748, São Paulo, SP, Brazil. Electronic address: henning@iq.usp.br.
  • DOI: 10.1016/j.brainresbull.2018.12.013 PMID: 30593881

    摘要 Ai翻译

    Neurogenesis is a process of generating functional neurons, which occurs during embryonic and adult stages in mammals. While neurogenesis during development phase is characterized by intensive proliferation activity in all regions of the brain to form the architecture and neural function of the nervous system, adult neurogenesis occurs with less intensity in two brain regions and is involved in the maintenance of neurogenic niches, local repair, memory and cognitive functions in the hippocampus. Taking such differences into account, the understanding of molecular mechanisms involved in cell differentiation in developmental stages and maintenance of the nervous system is an important research target. Although embryonic and adult neurogenesis presents several differences, signaling through purinergic receptors participates in this process throughout life. For instance, while embryonic neurogenesis involves P2X7 receptor down-regulation and calcium waves triggered by P2Y1 receptor stimulation, adult neurogenesis may be enhanced by increased activity of A2A and P2Y1 receptors and impaired by A1, P2Y13 and P2X7 receptor stimulation.

    Keywords: Adult neurogenesis; Embryonic neurogenesis; Purinergic signaling.

    Keywords:purinergic receptors; neurogenic processes

    Copyright © Brain research bulletin. 中文内容为AI机器翻译,仅供参考!

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    期刊名:Brain research bulletin

    缩写:BRAIN RES BULL

    ISSN:0361-9230

    e-ISSN:1873-2747

    IF/分区:3.5/Q2

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