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Cell death & disease. 2018 Apr 1;9(4):432. doi: 10.1038/s41419-018-0409-0 Q19.62025

BPIFB1 (LPLUNC1) inhibits radioresistance in nasopharyngeal carcinoma by inhibiting VTN expression

BPIFB1(LPLUNC1)通过抑制VTN表达抑制鼻咽癌放射抵抗性 翻译改进

Fang Wei  1  2  3, Le Tang  2, Yi He  2  4, Yingfen Wu  2, Lei Shi  2, Fang Xiong  1, Zhaojian Gong  2, Can Guo  2, Xiayu Li  2  3, Qianjin Liao  2  4, Wenling Zhang  2, Qianxi Ni  4, Jia Luo  4, Xiaoling Li  1  2  3, Yong Li  2  5, Cong Peng  1, Xiang Chen  1, Guiyuan Li  1  2  3, Wei Xiong  6  7  8, Zhaoyang Zeng  9  10  11

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作者单位

  • 1 The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • 2 The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.
  • 3 Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • 4 Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
  • 5 Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  • 6 The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.
  • 7 The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.
  • 8 Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.
  • 9 The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China. zengzhaoyang@csu.edu.cn.
  • 10 The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China. zengzhaoyang@csu.edu.cn.
  • 11 Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. zengzhaoyang@csu.edu.cn.

    • DOI: 10.1038/s41419-018-0409-0 PMID: 29568064

    摘要 Ai翻译

    Bactericidal/permeability-increasing-fold-containing family B member 1 (BPIFB1, previously named LPLUNC1) is highly expressed in the nasopharynx and significantly downregulated in nasopharyngeal carcinoma (NPC). Low expression is also associated with poor prognosis in patients with NPC. Radiotherapy is a routine treatment for NPC; however, radioresistance is a major cause of treatment failure. Thus, we aimed to investigate the role of BPIFB1 in the radiore... ...点击完成人机验证后继续浏览
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    期刊名：Cell death & disease

    缩写：CELL DEATH DIS

    ISSN：2041-4889

    e-ISSN：2041-4889

    IF/分区：9.6/Q1

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    BPIFB1 (LPLUNC1) inhibits radioresistance in nasopharyngeal carcinoma by inhibiting VTN expression