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AIDS (London, England). 2018 Aug 24;32(13):1773-1780. doi: 10.1097/QAD.0000000000001903 Q23.12025

Durable suppression of HIV-1 with resistance mutations to integrase inhibitors by dolutegravir following drug washout

整合酶抑制剂耐药突变的持续性抑制以及多替拉韦停药后的HIV-1抑制作用 翻译改进

Nathan Osman  1  2, Thibault Mesplède  1  2  3, Maureen Oliveira  1, Said Hassounah  1, Mark A Wainberg  1  2  4, Bluma G Brenner  1  2  3

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作者单位

  • 1 McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital.
  • 2 Department of Microbiology and Immunology.
  • 3 Division of Experimental Medicine.
  • 4 Department of Surgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
  • DOI: 10.1097/QAD.0000000000001903 PMID: 29894388

    摘要 Ai翻译

    Objectives: Dolutegravir (DTG) has achieved better long-term suppression of HIV-1 replication than other integrase strand transfer inhibitors (INSTIs), such as raltegravir (RAL) and elvitegravir (EVG). In in-vitro drug washout experiments, we previously showed that removal of DTG from pretreated MT-2 cells infected with wild-type HIV-1 showed slower rebound in viral replication as compared to removal of RAL. Now, we performed... ...点击完成人机验证后继续浏览
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    期刊名:Aids

    缩写:AIDS

    ISSN:0269-9370

    e-ISSN:1473-5571

    IF/分区:3.1/Q2

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    Durable suppression of HIV-1 with resistance mutations to integrase inhibitors by dolutegravir following drug washout