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Organic letters. 2015 Nov 6;17(21):5164-7. doi: 10.1021/acs.orglett.5b02410 Q15.02025

Palladium-Catalyzed Stereospecific Decarboxylative Benzylation of Alkynes

钯催化炔氢的立体选择性脱羧苄基化反应 翻译改进

Shehani N Mendis  1, Jon A Tunge  1

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作者单位

  • 1 Department of Chemistry, The University of Kansas , 2010 Malott Hall, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, United States.
  • DOI: 10.1021/acs.orglett.5b02410 PMID: 26450113

    摘要 Ai翻译

    Enantioenriched benzyl esters of propiolic acids undergo highly stereospecific decarboxylative coupling to provide 1,1-diarylethynyl methanes. This sp-sp(3) coupling does not require strongly basic conditions or preformed organometallics and produces CO2 as the sole byproduct. Ultimately, this method results in the successful transfer of stereochemical information from secondary benzyl alcohols to generate enantioenriched tertiary diarylmethanes.

    Keywords:palladium catalysis; decarboxylative benzylation; alkynes

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    期刊名:Organic letters

    缩写:ORG LETT

    ISSN:1523-7060

    e-ISSN:1523-7052

    IF/分区:5.0/Q1

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    Palladium-Catalyzed Stereospecific Decarboxylative Benzylation of Alkynes