Enantioenriched benzyl esters of propiolic acids undergo highly stereospecific decarboxylative coupling to provide 1,1-diarylethynyl methanes. This sp-sp(3) coupling does not require strongly basic conditions or preformed organometallics and produces CO2 as the sole byproduct. Ultimately, this method results in the successful transfer of stereochemical information from secondary benzyl alcohols to generate enantioenriched tertiary diarylmethanes.
Organic letters. 2015 Nov 6;17(21):5164-7. doi: 10.1021/acs.orglett.5b02410 Q15.02025
Palladium-Catalyzed Stereospecific Decarboxylative Benzylation of Alkynes
钯催化炔氢的立体选择性脱羧苄基化反应 翻译改进
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DOI: 10.1021/acs.orglett.5b02410 PMID: 26450113
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