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Review American journal of physiology. Cell physiology. 2016 Feb 15;310(4):C243-59. doi: 10.1152/ajpcell.00328.2015 Q14.72025

An unexpected journey: conceptual evolution of mechanoregulated potassium transport in the distal nephron

一段意想不到的旅程:远曲小管力学调控钾转运的概念演变 翻译改进

Rolando Carrisoza-Gaytan  1, Marcelo D Carattino  2, Thomas R Kleyman  2, Lisa M Satlin  3

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作者单位

  • 1 Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York; and.
  • 2 Renal-Electrolyte Division, Department of Medicine, Pittsburgh, Pennsylvania.
  • 3 Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York; and lisa.satlin@mssm.edu.
  • DOI: 10.1152/ajpcell.00328.2015 PMID: 26632600

    摘要 Ai翻译

    Flow-induced K secretion (FIKS) in the aldosterone-sensitive distal nephron (ASDN) is mediated by large-conductance, Ca(2+)/stretch-activated BK channels composed of pore-forming α-subunits (BKα) and accessory β-subunits. This channel also plays a critical role in the renal adaptation to dietary K loading. Within the ASDN, the cortical collecting duct (CCD) is a major site for the final renal regulation of K homeostasis. Principal cells in the ASDN poss... ...点击完成人机验证后继续浏览
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    期刊名:American journal of physiology-cell physiology

    缩写:AM J PHYSIOL-CELL PH

    ISSN:0363-6143

    e-ISSN:1522-1563

    IF/分区:4.7/Q1

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    An unexpected journey: conceptual evolution of mechanoregulated potassium transport in the distal nephron