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Journal of immunology (Baltimore, Md. : 1950). 2016 Mar 15;196(6):2439-43. doi: 10.4049/jimmunol.1501958 Q23.62024

Cutting Edge: The RIG-I Ligand 3pRNA Potently Improves CTL Cross-Priming and Facilitates Antiviral Vaccination

RIG-I配体3pRNA可有效增强交叉递呈和抗病毒疫苗免疫效果 翻译改进

Katharina Hochheiser  1, Marika Klein  2, Catherine Gottschalk  2, Florian Hoss  2, Stefanie Scheu  3, Christoph Coch  4, Gunther Hartmann  4, Christian Kurts  1

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作者单位

  • 1 Institute of Experimental Immunology, Rheinische Friedrich-Wilhelms University, Bonn 53105, Germany; khochhei@gmail.com ckurts@web.de.
  • 2 Institute of Experimental Immunology, Rheinische Friedrich-Wilhelms University, Bonn 53105, Germany;
  • 3 Institute of Medical Microbiology and Hospital Hygiene, University of Düsseldorf, Düsseldorf 40225, Germany; and.
  • 4 Institute of Clinical Chemistry and Clinical Pharmacology, Bonn 53127, Germany.
  • DOI: 10.4049/jimmunol.1501958 PMID: 26819202

    摘要 Ai翻译

    Protective immunity against intracellular pathogens involves the induction of robust CTL responses. Vaccination with protein Ags establishes such responses only when combined with immune-stimulatory adjuvants. In this study, we compared different adjuvants and identified triphosphate RNA (3pRNA) as especially effective at inducing CTL responses. 3pRNA sensing required IPS-1/MAVS signaling and induced type I IFN in plasmacytoid dendritic cells and macrophages, with the latter being more important for the adjuvant effect. Type I IFN acted on CD11c(+) cells, especially on CD8α(+) Batf3-dependent dendritic cells. Vaccination with OVA in combination with 3pRNA protected mice from a subsequent OVA-encoding adenovirus infection in a CD8(+) cell-dependent manner and more efficiently than other adjuvants. In summary, 3pRNA is a superior adjuvant for CTL activation and might be useful to facilitate antiviral immunization strategies.

    Keywords:rig-i ligand; 3prna; ctl cross-priming; antiviral vaccination

    Copyright © Journal of immunology (Baltimore, Md. : 1950). 中文内容为AI机器翻译,仅供参考!

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    期刊名:Journal of immunology

    缩写:J IMMUNOL

    ISSN:0022-1767

    e-ISSN:1550-6606

    IF/分区:3.6/Q2

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    Cutting Edge: The RIG-I Ligand 3pRNA Potently Improves CTL Cross-Priming and Facilitates Antiviral Vaccination