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Angewandte Chemie (International ed. in English). 2016 Mar 1;55(10):3369-72. doi: 10.1002/anie.201510518 Q116.92025

An Intrinsically Disordered Peptide Facilitates Non-Endosomal Cell Entry

一种内在无序肽可促进非内体细胞进入 翻译改进

Scott H Medina  1, Stephen E Miller  1, Allison I Keim  1, Alexander P Gorka  1, Martin J Schnermann  1, Joel P Schneider  2

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作者单位

  • 1 Chemical Biology Laboratory, National Cancer Institute, National Institutes of Health Fort Detrick, 376 Boyle Street, Frederick, MD, 21702-1201, USA.
  • 2 Chemical Biology Laboratory, National Cancer Institute, National Institutes of Health Fort Detrick, 376 Boyle Street, Frederick, MD, 21702-1201, USA. Joel.Schneider@nih.gov.

    • DOI: 10.1002/anie.201510518 PMID: 26835878

    摘要 Ai翻译

    Many cell-penetrating peptides (CPPs) fold at cell surfaces, adopting α- or β-structure that enable their intracellular transport. However, the same structural folds that facilitate cellular entry can also elicit potent membrane-lytic activity, limiting their use in delivery applications. Further, a distinct CPP can enter cells through many mechanisms, often leading to endosomal entrapment. Herein, we describe an intrinsically disordered peptide (CLIP6) ... ...点击完成人机验证后继续浏览
    Copyright © Angewandte Chemie (International ed. in English). 中文内容为AI机器翻译，仅供参考！

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    期刊名：Angewandte chemie-international edition

    缩写：ANGEW CHEM INT EDIT

    ISSN：N/A

    e-ISSN：1521-3773

    IF/分区：16.9/Q1

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    An Intrinsically Disordered Peptide Facilitates Non-Endosomal Cell Entry