We synthesized methoxy poly(ethylene glycol) (MPEG)-chlórin e6 (Ce6) conjugates to increase aqueous solubility of Ce6, to fabricate nanoparticles, and to improve tumor targetability of Ce6. MPEG-Ce6 conjugates (abbreviated as Pe6) associated in the aqueous solution as a nanoparticle. Pe6 nanoparticles have small diameter less than 100 nm, spherical shape, and core-shell structure in the aqueous environment. They have improved photophysical properties compared to Ce6 itself. Photosensitivity of Pe6 nanoparticles were studied using HCT116 human colon carcinoma cells. Pe6 nanoparticles practically have no dark-toxicity against HCT116 human colon carcinoma cells while they showed enhanced cellular uptake, phototoxicity, and ROS generation at in vitro cell culture experiment. Furthermore, they showed improved tumor tissue penetration and accumulation in vivo animal studies. We suggested Pe6 nanoparticles as an ideal candidate for PDT of colon cancer.
Journal of nanoscience and nanotechnology. 2016 Feb;16(2):1379-83. doi: 10.1166/jnn.2016.11922 0.02024
Nano-Self Assembled Photosensitizer Composed of Methoxy Poly(ethylene glycol)-Conjugated Chlorin e6 for Enhanced Photosensing of HCT116 Cells
由甲氧基聚乙二醇结合胆绿素e6组成的纳米自组装光敏剂用于增强HCT116细胞的光感化作用 翻译改进
作者单位 +展开
作者单位
DOI: 10.1166/jnn.2016.11922 PMID: 27433590
摘要 Ai翻译
Keywords：chlorin e6
相关内容
-
Antimicrobial photodynamic therapy using chlorin e6 with halogen light for acne bacteria-induced inflammation
使用氯化E6和卤素光的抗菌光动力疗法治疗由痤疮细菌引起的炎症
Life sciences. 2015 Mar 1:124:56-63.
-
Acetal-Linked Hyperbranched Polyphosphoester Nanocarriers Loaded with Chlorin e6 for pH-Activatable Photodynamic Therapy
负载血红素e6的基于缩酮连接的超支化聚磷酸酯纳米载体用于酸激活的光动力治疗
ACS applied materials & interfaces. 2018 Jun 27;10(25):21198-21205.
-
In vitro characterization of monoaspartyl chlorin e6 and diaspartyl chlorin e6 for photodynamic therapy
氯茵吴单天冬氨酸酯和双天冬氨酸酯光动力治疗的体外研究
Journal of the National Cancer Institute. 1988 May 4;80(5):330-6.
-
Synthesis of chlorin e6-transferrin and demonstration of its light-dependent in vitro breast cancer cell killing ability
叶绿素e6-转铁蛋白的合成及光依赖杀伤乳腺癌细胞能力的研究
Breast cancer research and treatment. 2002 Mar;72(2):117-30.
-
HPLC study of chlorin e6 and its molecular complex with polyvinylpyrrolidone
高效液相色谱法研究氯霉素e6及其与聚乙烯吡咯酮的分子复合物
Biomedical chromatography : BMC. 2007 Mar;21(3):318-25.
-
Insulin-mediated intracellular targeting enhances the photodynamic activity of chlorin e6
胰岛素介导的细胞内定位能增强血红素e6的光动力活性
Cancer research. 1995 Mar 1;55(5):1014-9.
-
Safety and Efficacy of Photodynamic Therapy with Chlorin E6 in Chronic Central Serous Chorioretinopathy
氯乙六烃贯叶连翘素光动力疗法治疗慢性中心性浆液性脉络膜视网膜病变的安全性和有效性研究
Retina (Philadelphia, Pa.). 2024 Mar 13.
-
Three-in-one: exploration of co-encapsulation of cabazitaxel, bicalutamide and chlorin e6 in new mixed cyclodextrin-crosslinked polymers
三合一：卡巴他赛、比卡鲁胺和氯合素E6共包封于新型混合环糊精交联聚合物中的探索研究
RSC advances. 2023 Apr 6;13(16):10923-10939.
