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Review Zhongguo shi yan xue ye xue za zhi. 2016 Aug;24(4):1269-74. doi: 10.7534/j.issn.1009-2137.2016.04.058 0.02025

[PI3K/AKT/mTOR Pathway and Pediatric T Acute Lymphoblastic Leukemia-Review]

[磷脂酰肌醇3激酶/蛋白激酶B/哺乳动物雷帕霉素靶点信号转导通路与T细胞急性淋巴细胞白血病的研究进展] 翻译改进

Article in Chinese

Li-Xiao Shi  1, Jian-Hua Wang  2, Xiao-Dong Shi  3

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作者单位

  • 1 Department of Hematology, Capital Institute of Pediatrics, Beijing 100020, China.
  • 2 Beijing Municipal Key Laboratory of Child Deve-lopment and Nutrions, Capital Institute of Pediatrics, Beijing 100020, China.
  • 3 Department of Hematology, Capital Institute of Pediatrics, Beijing 100020, China.E-mail:xsusan28@gmail.com.

    • DOI: 10.7534/j.issn.1009-2137.2016.04.058 PMID: 27531814

    摘要 Ai翻译

    The PI3K/Akt/mTOR signaling pathway plays a central role in cell growth, proliferation and survival in physiological conditions. This signal pathway is considered to be an innovative targeted therapy of cancer, and its abnormal activation has been proved to be related to T-cell acute lymphoblastic leukemia (T-ALL) .Despite improved treatment strategies, such as multi-drug combination, high-dose chemotherapy and all kinds of application and popularization of hematopoietic stem cell transplantation, children with drug resistance or relapse T-ALL are still rather worse and its overall outcome and prognosis are much poorer than the more common B-lineage ALL. Therefore, more effective and less cytotoxic treatment targeted strategies for leukemia greatly needed. This review focuses on the relationship between the PI3k/Akt/mTOR pathway and the pediatric T-ALL, so as to reveal the exact molecular mechanism of T-ALL and provide more directions for its treatment.

    Keywords：pi3k/aktpathway

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    关键词：PI3K/AKT信号通路

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    期刊名：Zhongguo shi yan xue ye xue za zhi / zhongguo bing li sheng li xue hui = journal of experimental he

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    ISSN：1009-2137

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