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Medical engineering & physics. 2014 Aug;36(8):1033-40. doi: 10.1016/j.medengphy.2014.05.006 Q32.32025

Design of tissue engineering scaffolds based on hyperbolic surfaces: structural numerical evaluation

基于双曲面的组织工程支架设计:结构数值评估 翻译改进

Henrique A Almeida  1, Paulo J Bártolo  2

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作者单位

  • 1 Centre for Rapid and Sustainable Product Development, School of Technology and Management, Polytechnic Institute of Leiria, Portugal. Electronic address: henrique.almeida@ipleiria.pt.
  • 2 Centre for Rapid and Sustainable Product Development, Polytechnic Institute of Leiria, Portugal Manchester Biomanufacturing Centre, School of Mechanical, Aerospace and Civil Engineering, Manchester Institute of Biotechnology, University of Manchester, UK.
  • DOI: 10.1016/j.medengphy.2014.05.006 PMID: 24935150

    摘要 Ai翻译

    Tissue engineering represents a new field aiming at developing biological substitutes to restore, maintain, or improve tissue functions. In this approach, scaffolds provide a temporary mechanical and vascular support for tissue regeneration while tissue in-growth is being formed. These scaffolds must be biocompatible, biodegradable, with appropriate porosity, pore structure and distribution, and optimal vascularization with both surface and structural compatibility. The challenge is to establish a proper balance between porosity and mechanical performance of scaffolds. This work investigates the use of two different types of triple periodic minimal surfaces, Schwarz and Schoen, in order to design better biomimetic scaffolds with high surface-to-volume ratio, high porosity and good mechanical properties. The mechanical behaviour of these structures is assessed through the finite element method software Abaqus. The effect of two parametric parameters (thickness and surface radius) is also evaluated regarding its porosity and mechanical behaviour.

    Keywords: Hyperbolic surfaces; Numerical simulation; Scaffolds; Structural analysis; Tissue engineering.

    Keywords:tissue engineering scaffolds; hyperbolic surfaces

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    期刊名:Medical engineering & physics

    缩写:MED ENG PHYS

    ISSN:1350-4533

    e-ISSN:1873-4030

    IF/分区:2.3/Q3

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    Design of tissue engineering scaffolds based on hyperbolic surfaces: structural numerical evaluation