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Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2014 Oct;35(10):9735-41. doi: 10.1007/s13277-014-2226-0 0.02025

Down regulation of mammalian target of rapamycin decreases HIF-1α and survivin expression in anoxic lung adenocarcinoma A549 cell to elemene and/or irradiation

哺乳动物雷帕霉素靶蛋白下调抑制射线和/或艾素诱导的人肺腺癌A549细胞缺氧条件下HIF-1α和Survivin的表达 翻译改进

Kun Zou  1, Enjuan Tong, Yinghui Xu, Xiaoqin Deng, Lijuan Zou

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  • 1 First Affiliated Hospital of Dalian Medical University, 222 Zhong Shan Road, Dalian, 116011, Liaoning, China.
  • DOI: 10.1007/s13277-014-2226-0 PMID: 24972968

    摘要 Ai翻译

    Mammalian target of rapamycin (mTOR) is associated with gene transcription, protein translation and initiation, the synthesis of ribosomes, and apoptosis. The down regulation of mTOR induces apoptosis in malignant tumor cells. Elemene, a sesquiterpene from the traditional Chinese medicinal herb Curcuma wenyujin, is active against a wide range of tumor types. In the present study, decreasing the expression of mTOR with mTOR small interfering RNA (siRNA) inc... ...点击完成人机验证后继续浏览
    Copyright © Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 中文内容为AI机器翻译,仅供参考!

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    期刊名:Tumor biology

    缩写:TUMOR BIOL

    ISSN:1010-4283

    e-ISSN:1423-0380

    IF/分区:0.0/

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    Down regulation of mammalian target of rapamycin decreases HIF-1α and survivin expression in anoxic lung adenocarcinoma A549 cell to elemene and/or irradiation