首页 正文

Biochemistry. 2015 Apr 7;54(13):2227-39. doi: 10.1021/acs.biochem.5b00079 Q33.02025

Mechanism of drug-drug interactions mediated by human cytochrome P450 CYP3A4 monomer

人CYP3A4单体介导的药物相互作用机制研究 翻译改进

Ilia G Denisov  1, Yelena V Grinkova  1, Javier L Baylon  1, Emad Tajkhorshid  1, Stephen G Sligar  1

作者单位 +展开

作者单位

  • 1 †Department of Biochemistry, ‡Center for Biophysics and Computational Biology, and §Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
  • DOI: 10.1021/acs.biochem.5b00079 PMID: 25777547

    摘要 Ai翻译

    Using Nanodiscs, we quantitate the heterotropic interaction between two different drugs mediated by monomeric CYP3A4 incorporated into a nativelike membrane environment. The mechanism of this interaction is deciphered by global analysis of multiple-turnover experiments performed under identical conditions using the pure substrates progesterone (PGS) and carbamazepine (CBZ) and their mixtures. Activation of CBZ epoxidation and simultaneous inhibition of PGS... ...点击完成人机验证后继续浏览
    Copyright © Biochemistry. 中文内容为AI机器翻译,仅供参考!

    相关内容

    期刊名:Biochemistry

    缩写:BIOCHEMISTRY-US

    ISSN:0006-2960

    e-ISSN:1520-4995

    IF/分区:3.0/Q3

    文章目录 更多期刊信息

    全文链接
    引文链接
    复制
    已复制!
    推荐内容
    Mechanism of drug-drug interactions mediated by human cytochrome P450 CYP3A4 monomer