Angewandte Chemie (International ed. in English). 2015 Jun 1;54(23):6740-4. doi: 10.1002/anie.201412493 Q116.92025

Dendrimeric siRNA for Efficient Gene Silencing

高效基因沉默的树形siRNA 翻译改进

Cheol Am Hong¹, Ahmed A Eltoukhy², Hyukjin Lee³, Robert Langer², Daniel G Anderson⁴, Yoon Sung Nam⁵

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作者单位

¹ Department of Biological Sciences, Department of Materials Science and Engineering, KI for NanoCentury (KINC CNiT), Korea Advanced Institute of Science and Technology, Daejeon 305-701 (Republic of Korea).

² Department of Biological Engineering, The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA).

³ Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul (Republic of Korea).

⁴ Department of Biological Engineering, The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA). dgander@mit.edu.

⁵ Department of Biological Sciences, Department of Materials Science and Engineering, KI for NanoCentury (KINC CNiT), Korea Advanced Institute of Science and Technology, Daejeon 305-701 (Republic of Korea). yoonsung@kaist.ac.kr.

DOI: 10.1002/anie.201412493 PMID: 25892329

摘要 Ai翻译

Programmable molecular self-assembly of siRNA molecules provides precisely controlled generation of dendrimeric siRNA nanostructures. The second-generation dendrimers of siRNA can be effectively complexed with a low-molecular-weight, cationic polymer (poly(β-amino ester), PBAE) to generate stable nanostructures about 160 nm in diameter via strong electrostatic interactions. Condensation and gene silencing efficiencies increase with the increased generation of siRNA dendrimers due to a high charge density and structural flexibility.

Keywords: dendrimeric nanostructures; gene silencing; poly(β-amino ester); polymeric condensation; siRNA.

Keywords：dendrimeric siRNA; gene silencing

关键词：树枝状siRNA; 基因沉默

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期刊名：Angewandte chemie-international edition

缩写：ANGEW CHEM INT EDIT

ISSN：N/A

e-ISSN：1521-3773

IF/分区：16.9/Q1

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