Catharanthus roseus monoterpene indole alkaloid analogs have been produced via a combination of biosynthetic and chemical strategies. Specifically, introduction of a chemical handle-a chlorine or a bromine-into the target molecule by mutasynthesis, followed by postbiosynthetic chemical derivatization using Pd-catalyzed Suzuki-Miyaura cross-coupling reactions robustly afforded aryl and heteroaryl analogs of these alkaloids.
Organic letters. 2013 Jun 7;15(11):2850-3. doi: 10.1021/ol401179k Q15.02025
Diversification of monoterpene indole alkaloid analogs through cross-coupling
通过交叉偶联多样化单萜吲哚生物碱类化合物 翻译改进
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DOI: 10.1021/ol401179k PMID: 23713451
摘要 Ai翻译
Keywords：cross-coupling
关键词：单萜吲哚生物碱类似物; 交叉偶联反应
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