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Journal of neuroimmunology. 2012 May 15;246(1-2):43-50. doi: 10.1016/j.jneuroim.2012.03.004 Q32.52025

Neuroprotective effects of human umbilical cord mesenchymal stromal cells in an immunocompetent animal model of Parkinson's disease

人脐带间充质基质细胞对免疫competent动物帕金森病模型的神经保护作用 翻译改进

Patricia Mathieu  1, Valeria Roca, Cecilia Gamba, Ana Del Pozo, Fernando Pitossi

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  • 1 Laboratory of Regenerative and Protective Therapies of the Nervous System, Foundation Leloir Institute, IIBBA-CONICET, 435 Av Patricias Argentinas, 1405 Buenos Aires, Argentina.
  • DOI: 10.1016/j.jneuroim.2012.03.004 PMID: 22458982

    摘要 Ai翻译

    Microglial activation in the substantia nigra (SN) is a ubiquitous feature in PD which could mediate toxic effects. Human mesenchymal stromal cells (hMSCs) possess immunomodulatory properties. We evaluated whether the transplantation of hMSCs obtained from umbilical cord had a neuroprotective effect in a not-immunosuppressed rat Parkinson's disease (PD) model. Rats receiving hMSCs in the SN displayed significant preservation in the number of dopaminergic n... ...点击完成人机验证后继续浏览
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    期刊名:Journal of neuroimmunology

    缩写:J NEUROIMMUNOL

    ISSN:0165-5728

    e-ISSN:1872-8421

    IF/分区:2.5/Q3

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    Neuroprotective effects of human umbilical cord mesenchymal stromal cells in an immunocompetent animal model of Parkinson's disease