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Comparative Study The European journal of neuroscience. 2005 Oct;22(7):1799-806. doi: 10.1111/j.1460-9568.2005.04362.x Q32.42025

Neuroprotective effects of metabotropic glutamate receptor ligands in a 6-hydroxydopamine rodent model of Parkinson's disease

代谢型谷氨酸受体配体在6-羟基多巴胺建立的帕金森病动物模型中的神经保护作用 翻译改进

A C Vernon  1, S Palmer, K P Datla, V Zbarsky, M J Croucher, D T Dexter

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  • 1 Parkinson's Disease Research Group, Department of Cellular and Molecular Neuroscience, Faculty of Medicine, Imperial College London, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK.
  • DOI: 10.1111/j.1460-9568.2005.04362.x PMID: 16197521

    摘要 Ai翻译

    Increasing evidence implicates glutamate-mediated excitotoxicity as a contributory factor in dopaminergic cell death in the substantia nigra pars compacta (SNc) in Parkinson's disease (PD). Previous studies have suggested that metabotropic glutamate receptor (mGluR) ligands are neuroprotective against excitotoxicity in vitro. In the present study, the neurotoxin 6-hydroxydopamine (6-OHDA) produced a significant loss (61.2 +/- 8.9%; P < 0.01) of tyrosine hy... ...点击完成人机验证后继续浏览
    Copyright © The European journal of neuroscience. 中文内容为AI机器翻译,仅供参考!

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    期刊名:European journal of neuroscience

    缩写:EUR J NEUROSCI

    ISSN:0953-816X

    e-ISSN:1460-9568

    IF/分区:2.4/Q3

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    Neuroprotective effects of metabotropic glutamate receptor ligands in a 6-hydroxydopamine rodent model of Parkinson's disease