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American journal of respiratory cell and molecular biology. 2012 Jun;46(6):823-32. doi: 10.1165/rcmb.2011-0110OC Q15.32025

Regulator of G-protein signaling-5 inhibits bronchial smooth muscle contraction in severe asthma

G蛋白信号调节素-5通过抑制重度哮喘患者气道平滑肌收缩发挥保护作用 翻译改进

Zhao Yang  1, Nariman Balenga, Philip R Cooper, Gautam Damera, Richard Edwards, Christopher E Brightling, Reynold A Panettieri Jr, Kirk M Druey

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作者单位

  • 1 Molecular Signal Transduction Section, Laboratory of Allergic Diseases, National Insitute of Allergy and Infectious Diseases/NIH, 10 Center Drive, Bethesda, MD 20982, USA. kdruey@niaid.nih.gov
  • DOI: 10.1165/rcmb.2011-0110OC PMID: 22281988

    摘要 Ai翻译

    Severe asthma is associated with fixed airway obstruction attributable to inflammation, copious luminal mucus, and increased airway smooth muscle (ASM) mass. Paradoxically, studies demonstrated that the hypertrophic and hyperplastic ASM characteristic of severe asthma has reduced contractile capacity. We compared the G-protein-coupled receptor (GPCR)-induced Ca(2+) mobilization and expression of GPCRs and signaling proteins related to procontractile signal... ...点击完成人机验证后继续浏览
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    期刊名:American journal of respiratory cell and molecular biology

    缩写:AM J RESP CELL MOL

    ISSN:1044-1549

    e-ISSN:1535-4989

    IF/分区:5.3/Q1

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    Regulator of G-protein signaling-5 inhibits bronchial smooth muscle contraction in severe asthma