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Nutrition research (New York, N.Y.). 2012 Jan;32(1):66-9. doi: 10.1016/j.nutres.2011.11.005 Q23.42024

Ascorbate and dehydroascorbic acid as biomarkers of oxidative stress: validity of clinical data depends on vacutainer system used

抗坏血酸和脱氢抗坏血酸作为氧化应激的生物标志物:临床数据的有效性取决于使用的Vacutainer系统 翻译改进

Jens Lykkesfeldt  1

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作者单位

  • 1 Section of Biomedicine, Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, DK-1870 Frederiksberg C, Denmark. jopl@life.ku.dk
  • DOI: 10.1016/j.nutres.2011.11.005 PMID: 22260866

    摘要 Ai翻译

    Ascorbate and dehydroascorbic acid are frequently used as biomarkers of oxidative stress, but their lack of stability ex vivo and rapid postsampling interconversion continue to result in erroneous reference values. One problem is the large variety of vacutainer devices used for blood sampling purposes and the basic question of plasma vs serum as matrix. This study acquired blood samples by using 9 different and commonly used vacutainer systems followed by acidic stabilization and analysis by a well-validated method with the purpose of identifying acceptable means of collecting samples for proper ascorbate/dehydroascorbic acid analysis. In comparison, K(3)-EDTA vacutainers were superior in maintaining low ex vivo oxidation of vitamin C.

    Keywords:oxidative stress; biomarkers

    Copyright © Nutrition research (New York, N.Y.). 中文内容为AI机器翻译,仅供参考!

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    期刊名:Nutrition research

    缩写:NUTR RES

    ISSN:0271-5317

    e-ISSN:1879-0739

    IF/分区:3.4/Q2

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    Ascorbate and dehydroascorbic acid as biomarkers of oxidative stress: validity of clinical data depends on vacutainer system used