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Neuroreport. 2011 Sep 14;22(13):637-41. doi: 10.1097/WNR.0b013e328349739b Q41.72025

Evidence that clozapine directly interacts on the GABAB receptor

氯氮平直接与GABAB受体相互作用的证据 翻译改进

Ying Wu  1, Monica Blichowski, Zafiris J Daskalakis, Zhouyou Wu, Chun C Liu, Miguel A Cortez, Orlando Carter Snead 3rd

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  • 1 Program in Neuroscience and Mental Health, University of Toronto fCentre for Addiction and Mental Health, Toronto, Ontario, Canada.
  • DOI: 10.1097/WNR.0b013e328349739b PMID: 21753741

    摘要 Ai翻译

    Neurophysiological studies suggest that clozapine may facilitate γ-aminobutyric acid (GABAergic) neurotransmission. Therefore, we studied the interaction between clozapine and the GABAB receptor (GABABR). We showed that clozapine, and not N-desmethylclozapine, which is a metabolite of clozapine, increased the binding of the GABABR antagonist, [³H]-CGP54626A, at GABABRs. Linear regression analysis showed that the correlation between the dose of clozapine ... ...
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    期刊名:Neuroreport

    缩写:NEUROREPORT

    ISSN:0959-4965

    e-ISSN:1473-558X

    IF/分区:1.7/Q4

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    Evidence that clozapine directly interacts on the GABAB receptor