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Comment Cell stem cell. 2011 Jun 3;8(6):604-5. doi: 10.1016/j.stem.2011.05.007 Q120.42025

Epigenetic modifications in distinction: histone versus DNA methylation in ESCs

表观遗传重编程的区别:胚胎干细胞中组蛋白与DNA甲基化差异 翻译改进

Kevin Huang  1, Guoping Fan

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  • 1 Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-7088, USA.
  • DOI: 10.1016/j.stem.2011.05.007 PMID: 21624801

    摘要 Ai翻译

    In this issue of Cell Stem Cell, Karimi et al. (2011) show that DNA methylation and histone H3 lysine 9 trimethylation (H3K9me3) have distinct genomic targets in mouse ESCs. In particular, loss of H3K9me3 leads to derepression of select endogenous retroviruses and subsequent ectopic transcription of adjacent genes.

    Keywords:epigenetic modifications; histone methylation; dna methylation

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    期刊名:Cell stem cell

    缩写:CELL STEM CELL

    ISSN:1934-5909

    e-ISSN:1875-9777

    IF/分区:20.4/Q1

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    Epigenetic modifications in distinction: histone versus DNA methylation in ESCs