Comparative Study Archiv der Pharmazie. 2004 Jan;337(1):35-41. doi: 10.1002/ardp.200300816 Q23.62025

Synthesis and structure-activity relationships of 4-cycloalkylamino-1, 2, 4-triazolo[4, 3-a]quinoxalin-1- one derivatives as A1 and A3 adenosine receptor antagonists

一类新型的A₁和A₃腺苷受体拮抗剂——4-环烷基氨基-1,2,4-三唑并[4,3-a]喹喔啉-1-酮类化合物的设计、合成及构效关系研究翻译改进

Vittoria Colotta¹, Daniela Catarzi, Flavia Varano, Guido Filacchioni, Claudia Martini, Letizia Trincavelli, Antonio Lucacchini, Vittoria Colotta

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¹ Dipartimento di Scienze Farmaceutiche, Universita' di Firenze, Firenze, Italy. vittoria.colotta@unifi.it

DOI: 10.1002/ardp.200300816 PMID: 14760626

摘要 Ai翻译

In a previous paper we reported the synthesis and binding activity of 4-cycloalkylamino-1, 2, 4-triazolo[4, 3-a]quinoxalin-1-one derivatives, differently substituted on the appended 2-phenyl ring, some of which were potent and selective A(1) adenosine receptor (AR) antagonists. In the present paper several 4-cycloalkylamino-2-phenyl-1, 2, 4-triazolo[4, 3-a]quinoxalin-1-one derivatives (1-11), bearing simple substituents on the benzofused moiety, are report... ...点击完成人机验证后继续浏览

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期刊名：Archiv der pharmazie

缩写：ARCH PHARM

ISSN：0365-6233

e-ISSN：1521-4184

IF/分区：3.6/Q2

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Synthesis and structure-activity relationships of 4-cycloalkylamino-1, 2, 4-triazolo[4, 3-a]quinoxalin-1- one derivatives as A1 and A3 adenosine receptor antagonists

一类新型的A₁和A₃腺苷受体拮抗剂——4-环烷基氨基-1,2,4-三唑并[4,3-a]喹喔啉-1-酮类化合物的设计、合成及构效关系研究翻译改进

The discovery and synthesis of novel adenosine receptor (A(2A)) antagonists

新型腺苷受体(A2A)拮抗剂的发现和合成

Angiotensin converting enzyme inhibition prevents trophic and hypertensive effects of an antagonist of adenosine receptors

血管紧张素转换酶抑制可防止腺苷受体拮抗剂的营养和高血压效应

Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists

具有高选择性和较强活性的人A3腺苷受体拮抗剂并[4，3-e][1，5-c]嘧啶衍生物研究进展

ST 1535: a preferential A2A adenosine receptor antagonist

ST1535：一种偏向性的A2A腺苷受体拮抗剂

SCH 58261, an A(2A) adenosine receptor antagonist, counteracts parkinsonian-like muscle rigidity in rats

SCH 58261，一种A2A腺苷受体拮抗剂，可改善类似帕金森病的肌肉强直症状小鼠模型中的症状

KF17837 is an A2 adenosine receptor antagonist in vivo

KF17837是一个A2A腺苷受体拮抗剂

Study of the novel non-xanthine heterocyclic compound GU285 as a potent non-selective adenosine receptor antagonist in the rat

大鼠非选择性腺苷受体拮抗剂新类型杂环化合物GU285的研究

Discriminative effects of CGS 15943, a competitive adenosine receptor antagonist, in monkeys: comparison to methylxanthines

竞争性腺苷受体拮抗剂CGS15943在猴脑内的识别效应与甲基黄嘌呤的比较研究

Synthesis and structure-activity relationships of 4-cycloalkylamino-1, 2, 4-triazolo[4, 3-a]quinoxalin-1- one derivatives as A1 and A3 adenosine receptor antagonists

一类新型的A₁和A₃腺苷受体拮抗剂——4-环烷基氨基-1,2,4-三唑并[4,3-a]喹喔啉-1-酮类化合物的设计、合成及构效关系研究 翻译改进

The discovery and synthesis of novel adenosine receptor (A(2A)) antagonists

新型腺苷受体(A2A)拮抗剂的发现和合成

Angiotensin converting enzyme inhibition prevents trophic and hypertensive effects of an antagonist of adenosine receptors

血管紧张素转换酶抑制可防止腺苷受体拮抗剂的营养和高血压效应

Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists

具有高选择性和较强活性的人A3腺苷受体拮抗剂并[4，3-e][1，5-c]嘧啶衍生物研究进展

ST 1535: a preferential A2A adenosine receptor antagonist

ST1535：一种偏向性的A2A腺苷受体拮抗剂

SCH 58261, an A(2A) adenosine receptor antagonist, counteracts parkinsonian-like muscle rigidity in rats

SCH 58261，一种A2A腺苷受体拮抗剂，可改善类似帕金森病的肌肉强直症状小鼠模型中的症状

KF17837 is an A2 adenosine receptor antagonist in vivo

KF17837是一个A2A腺苷受体拮抗剂

Study of the novel non-xanthine heterocyclic compound GU285 as a potent non-selective adenosine receptor antagonist in the rat

大鼠非选择性腺苷受体拮抗剂新类型杂环化合物GU285的研究

Discriminative effects of CGS 15943, a competitive adenosine receptor antagonist, in monkeys: comparison to methylxanthines

竞争性腺苷受体拮抗剂CGS15943在猴脑内的识别效应与甲基黄嘌呤的比较研究

一类新型的A₁和A₃腺苷受体拮抗剂——4-环烷基氨基-1,2,4-三唑并[4,3-a]喹喔啉-1-酮类化合物的设计、合成及构效关系研究翻译改进