In neurons, many different RNAs are targeted to dendrites where local expression of the encoded proteins mediates synaptic plasticity during learning and memory. It is not known whether each RNA follows a separate trafficking pathway or whether multiple RNAs are targeted to dendrites by the same pathway. Here, we show that RNAs encoding alpha calcium calmodulin-dependent protein kinase II, neurogranin, and activity-regulated cytoskeleton-associated protein are coassembled into the same RNA granules and targeted to dendrites by the same cis/trans-determinants (heterogeneous nuclear ribonucleoprotein [hnRNP] A2 response element and hnRNP A2) that mediate dendritic targeting of myelin basic protein RNA by the A2 pathway in oligodendrocytes. Multiplexed dendritic targeting of different RNAs by the same pathway represents a new organizing principle for coordinating gene expression at the synapse.
Molecular biology of the cell. 2008 May;19(5):2311-27. doi: 10.1091/mbc.e07-09-0914 Q32.72025
Multiplexed dendritic targeting of alpha calcium calmodulin-dependent protein kinase II, neurogranin, and activity-regulated cytoskeleton-associated protein RNAs by the A2 pathway
A2途径在α-钙调神经磷酸酶依赖蛋白激酶II、神经营养突触素和活动相关细胞骨架蛋白的靶向树突定位中的作用 翻译改进
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DOI: 10.1091/mbc.e07-09-0914 PMID: 18305102
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期刊名：Molecular biology of the cell
缩写：MOL BIOL CELL
ISSN：1059-1524
e-ISSN：1939-4586
IF/分区：2.7/Q3