The past approach of high-throughput screening of everything in the corporate collection has been shown to be very expensive in terms of reagents cost, disposal cost, and compound collection depletion. It is well known that screening campaigns produce several hits, of which only 50% confirm on average. More efficient ways of screening can provide an informative structure-activity relationship (SAR), which in turn can be used to build mathematical models for further probing the activity space and directing chemical synthesis. The authors report new methods and insights to extract the maximum possible information from a screening experiment and find most of the possible hits in the corporate collection while screening as few compounds as possible.
Journal of biomolecular screening. 2004 Dec;9(8):678-86. doi: 10.1177/1087057104269570 0.02024
Practical approaches to efficient screening: information-rich screening protocol
高效筛选的实用方法：信息丰富度高的筛选协议 翻译改进
作者单位 +展开
作者单位
DOI: 10.1177/1087057104269570 PMID: 15634794
摘要 Ai翻译
Keywords：efficient screening
相关内容
-
Optimized efficient screening for Duchenne muscular dystrophy carriers using proto-oncogene tyrosine-protein kinase receptor Ret
优化的RET基因筛选方法在抗凝血状态下的杜氏肌营养不良症携带者筛查中的应用研究
Laboratory medicine. 2025 Apr 17:lmae127.
-
Highly efficient screening and optimal combination of functional isolates for bioremediation of hydrocarbon-polluted soil
高效筛选及优化组合功能菌株用于石油污染土壤的生物修复研究
Environmental research. 2023 Feb 15:219:115064.
-
An efficient group screening test
一种高效的群体筛选试验方法
The Journal of speech disorders. 1952 Mar;17(1):8-12.
-
Efficient large-scale screening for the hemochromatosis susceptibility gene mutation
高效筛选遗传性血色素沉着症基因突变的方法
Blood. 1997 Oct 1;90(7):2848-9.
-
Efficient and effective screening for hydroxychloroquine toxicity
高效有效的羟氯喹毒性筛选方法
American journal of ophthalmology. 2013 Mar;155(3):413-4.
-
Designing combinatorial libraries for efficient screening
高效的筛选相结合的库的设计
Methods in molecular biology (Clifton, N.J.). 2002:201:307-23.
-
Cost-efficient screening for BK virus in pediatric kidney transplantation: a single-center experience and review of the literature
一种成本效益高的儿科肾移植受者的BK病毒筛查方法：单一中心经验和文献回顾
Pediatric transplantation. 2010 Aug;14(5):589-95.
-
How to screen for ACEs in an efficient, sensitive, and effective manner
高效、敏感且有效的ACE筛查方法
Paediatrics & child health. 2019 Feb;24(1):37-38.
