We followed 16 patients with a variety of mitochondrial diseases over one to four periods of treatment (2 months each) with coenzyme Q10 plus vitamins K3 and C, riboflavin, thiamine, and niacin, using independent measures of oxidative metabolism to assess efficacy. There were large (> threefold) increases in serum coenzyme Q10 concentrations with treatment, but no measure of oxidative metabolism showed significant improvement with treatment for the group, nor did any individual patient show significant, reproducible, objective clinical improvement. The results suggest that coenzyme Q10 plus vitamin therapy does not significantly improve mitochondrial oxidative metabolism in patients with mitochondrial disease in general. Any clinical benefit that may follow from short-term administration appears slight.
Neurology. 1993 May;43(5):884-90. doi: 10.1212/wnl.43.5.884 Q18.42024
Coenzyme Q10 with multiple vitamins is generally ineffective in treatment of mitochondrial disease
辅酶Q10联合多种维生素通常不能有效治疗线粒体疾病 翻译改进
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DOI: 10.1212/wnl.43.5.884 PMID: 8492942
摘要 Ai翻译
Keywords：coenzyme q10; multiple vitamins
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