To evaluate the effect of coenzyme Q10 in reducing postoperative cardiac complications after ischemia and reperfusion, we randomly divided 40 patients undergoing elective coronary artery bypass into two groups: patients in group 1 received coenzyme Q10 (150 mg/day) for 7 days before operation, and those in group 2 were the control group. Concentrations of thiobarbituric acid-reactive substances (malondialdehyde), conjugated dienes, and cardiac isoenzymes of creatine kinase were measured in samples from both arterial and coronary sinus sites. Serial sampling was performed 5 minutes after heparin administration, at 10 and 30 minutes during cardiopulmonary bypass, 15 and 30 minutes after aortic cross-clamp removal, and 5 minutes after protamine administration. The concentrations of malondialdehyde, conjugated dienes, and creatine kinase in group 1 were significantly lower than those in group 2. The decrease in plasma malondialdehyde concentrations correlated positively with the decrease in creatine kinase levels in the coronary sinus. The treatment group showed a significantly lower incidence of ventricular arrhythmias during the recovery period than did the control group (p < 0.05). Although the percentage of patients requiring inotropic agents was not significantly different between the two groups, the mean dosage of dopamine required to maintain stable hemodynamics was significantly lower in patients of group 1 than in those of group 2 (p < 0.01). Our findings suggest that pretreatment with coenzyme Q10 may play a protective role during routine bypass grafting by attenuating the degree of peroxidative damage.
Clinical Trial The Annals of thoracic surgery. 1994 Nov;58(5):1427-32. doi: 10.1016/0003-4975(94)91928-3 Q13.72024
Protection by coenzyme Q10 from myocardial reperfusion injury during coronary artery bypass grafting
辅酶Q10对冠状动脉旁路移植术中再灌注损伤的保护作用 翻译改进
作者单位 +展开
作者单位
DOI: 10.1016/0003-4975(94)91928-3 PMID: 7979670
摘要 Ai翻译
Keywords：coenzyme Q10
关键词：辅酶Q10
相关内容
-
Biopharmaceutical characterization of nanocrystalline solid dispersion of coenzyme Q10 prepared with cold wet-milling system
用于CoQ10纳米结晶固体分散体制备的冷湿磨系统的生物制药表征研究
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2014 Mar 12:53:118-25.
-
[Coenzyme Q10 and alpha-tocopherol in patients after heart transplantation]
[心脏移植患者血浆辅酶Q10和α-生育酚水平]
Bratislavske lekarske listy. 1996 Oct;97(10):603-6.
-
Effect of coenzyme-q10 on Doxorubicin-induced nephrotoxicity in rats
辅酶Q10对阿霉素致大鼠肾毒性的保护作用研究
Advances in pharmacological sciences. 2012:2012:981461.
-
Coenzyme Q10 protects against hyperlipidemia-induced cardiac damage in apolipoprotein E-deficient mice
辅酶Q10可保护载脂蛋白E缺乏型小鼠向高血压转变所致的心脏损害
Lipids in health and disease. 2018 Dec 8;17(1):279.
-
Coenzyme Q10
辅酶Q10
Alternative medicine review : a journal of clinical therapeutic. 1998 Feb;3(1):58-61.
-
Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris
辅酶Q10对慢性稳定型心绞痛运动耐力的影响
The American journal of cardiology. 1985 Aug 1;56(4):247-51.
-
[Application of orthogonal function spectrophotometry to the determination of the coenzyme Q10 content in the injection]
正交函数光度法测定辅酶Q10注射液中辅酶Q10的含量
Yao xue xue bao = Acta pharmaceutica Sinica. 1985 Feb;20(2):118-22.
-
Prevention of contrast induced-acute kidney injury using coenzyme Q10 in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention
辅酶Q10预防ST段抬高型心肌梗死患者行直接经皮冠状动脉介入术的对比剂致急性肾损伤风险
European journal of clinical pharmacology. 2023 Oct;79(10):1341-1356.
