A previous study has demonstrated that adaptive missense mutations occur in the trp operon of Escherichia coli. In this study it is shown that, under conditions of intense selection, a strain carrying missense mutations in both trpA and trpB reverts to Trp+ 10(8) times more frequently than would be expected if the two mutations were the result of independent events. Comparison of the single mutation rates with the double mutation rate and information obtained by sequencing DNA from double revertants show that neither our classical understanding of spontaneous mutation processes nor extant models for adaptive mutations can account for all of the observations. Despite a current lack of mechanistic understanding, it is clear that adaptive mutations can permit advantageous phenotypes that require multiple mutations to arise and that they appear enormously more frequently than would be expected.
Proceedings of the National Academy of Sciences of the United States of America. 1991 Jul 1;88(13):5882-6. doi: 10.1073/pnas.88.13.5882 Q19.42024
Adaptive evolution that requires multiple spontaneous mutations: mutations involving base substitutions
需要多个自发突变的适应性进化：碱基替换型突变 翻译改进
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DOI: 10.1073/pnas.88.13.5882 PMID: 2062865
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Keywords：adaptive evolution
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期刊名：Proceedings of the national academy of sciences of the united states of america
缩写：P NATL ACAD SCI USA
ISSN：0027-8424
e-ISSN：1091-6490
IF/分区：9.4/Q1