Abdullahi Magaji Dauda,Thomas Swift,Richard Telford et al.
Abdullahi Magaji Dauda et al.
Mitonafide-loaded liposomes are a promising strategy to overcome the neurotoxicity observed in clinical trials for this drug. This study investigates the influence of loaded mitonafide or a dimer analogue on different liposomal formulations...
Synthetic mucus barrier arrays as a nanoparticle formulation screening platform [0.03%]
合成黏液屏障阵列作为纳米粒子配方筛选平台
Harry Zou,Allison Boboltz,Yahya Cheema et al.
Harry Zou et al.
A mucus gel layer lines the luminal surface of tissues throughout the body to protect them from infectious agents and particulates. As a result, nanoparticle drug delivery systems delivered to these sites may become trapped in mucus and sub...
Dextrin conjugation to colistin inhibits its toxicity, cellular uptake and acute kidney injury in vivo [0.03%]
葡糖基化多粘菌素抑制其毒性、细胞摄取和体内急性肾损伤
Mathieu Varache,Siân Rizzo,Edward J Sayers et al.
Mathieu Varache et al.
The acute kidney injury (AKI) and dose-limiting nephrotoxicity, which occurs in 20-60% of patients following systemic administration of colistin, represents a challenge in the effective treatment of multi-drug resistant Gram-negative infect...
Molecular structure of ketoprofen-polyvinylpyrrolidone solid dispersions prepared by different amorphization methods [0.03%]
不同无定形化方法制备的酮洛芬-聚维酮固态分散物分子结构研究
Stephen K Wilke,Chris J Benmore,Vrishank Menon et al.
Stephen K Wilke et al.
Amorphous solid dispersions (ASDs) are a widely studied formulation approach for improving the bioavailability of poorly water-soluble pharmaceuticals. Yet, a complete understanding remains lacking for how specific processing methods may in...