Understanding the impact of vitamin D supplement formulation, quality and provision to older adults in UK residential care homes [0.03%]
理解维生素D补充剂配方、质量及为英国养老院老年人提供对维生素D的影响
N Rombel,C Lim,A Majeed et al.
N Rombel et al.
Supplying vitamin D supplements to all older adults is beneficial and cost-effective. However, operationalising this supply to residents in long-term care is problematic. This study aimed to understand the challenges of vitamin D supplement...
Comprehensive physicochemical, biophysical, and in vitro characterization of lung surfactant SP-A peptidomimetics [0.03%]
肺表面活性剂SP-A肽 mimetic的综合理化，生物物理和体外特征分析
David Encinas-Basurto,Priya Muralidharan,M D Saiful Islam et al.
David Encinas-Basurto et al.
Surfactant protein-A (SP-A) is an endogenous and essential lung surfactant-specific protein that is integral to pulmonary immunity, including inhibition of asthma exacerbations. This study aims to comprehensively characterize two peptides (...
Veena Vijayan,Janitha M Unagolla,Dhruvisha Panchal et al.
Veena Vijayan et al.
Liver fibrosis is a progressive and fatal condition characterized by stiffness and scarring of the liver due to excessive buildup of extracellular matrix (ECM) proteins. If left untreated, it can progress to liver cirrhosis and hepatocellul...
Standard purification methods are not sufficient to remove micellular lipophilic dye from polymer nanoparticle solution [0.03%]
标准纯化方法不足以从聚合物纳米粒子溶液中去除胶束亲脂性染料
Eric H Sterin,Laura A Weinstein,Chitran Roy Chowdhury et al.
Eric H Sterin et al.
Tracking nanoparticles' location is imperative for understanding cellular interactions, pharmacokinetics, and biodistribution. DiD is a lipophilic dye commonly used to label nanoparticles for trafficking studies. Herein, we show that DiD mi...
Polybasic nanogels for intracellular co-delivery of paclitaxel and carboplatin: a novel approach to ovarian cancer therapy [0.03%]
用于细胞内共传递紫杉醇和卡铂的多聚碱性纳米凝胶：卵巢癌治疗的新方法
Angela M Wagner,Olivia L Lanier,Ani Savk et al.
Angela M Wagner et al.
Ovarian cancer is one of the leading causes of cancer-related deaths in women, with limited progress in treatments despite decades of research. Common treatment protocols rely on surgical removal of tumors and chemotherapy drugs, such as pa...
On-demand release of encapsulated ZnO nanoparticles and chemotherapeutics for drug delivery applications [0.03%]
一种药物输送应用的封装ZnO纳米颗粒及化疗药物按需释放技术
Josh E Eixenberger,Catherine B Anders,Rebecca Hermann et al.
Josh E Eixenberger et al.
Nanomedicines offer high promise for the treatment of various diseases, and numerous novel approaches using nanomaterials have been developed over the years. In this report, we introduce a new strategy utilizing ZnO nanoparticles (nZnO) to ...
Microfluidics-generated PLA nanoparticles: impact of purification method on macrophage interactions, anti-inflammatory effects, biodistribution, and protein corona formation [0.03%]
基于微流控技术的聚乳酸纳米颗粒的纯化方法对其与巨噬细胞相互作用、抗炎效应、体内分布及蛋白冠形成的影响研究
Jacob R Shaw,Radha Vaidya,Fanny Xu et al.
Jacob R Shaw et al.
Polymeric nanoparticles (NPs) are traditionally formulated using batch methodologies that are poorly scalable and require time consuming, hands-on purification procedures. Here, we prepared poly(lactic acid) (PLA)-based polymeric NPs using ...
Comparison of emulsion and spray methods for fabrication of rapamycin-loaded acetalated dextran microparticles [0.03%]
comparison of emulsion and spray methods for the preparation of rapamycin-loaded acetalyted dextran micro particles
Stephen A Ehrenzeller,Nicole Rose Lukesh,Rebeca T Stiepel et al.
Stephen A Ehrenzeller et al.
Rapamycin (rapa), an immunosuppressive medication, has demonstrated considerable effectiveness in reducing organ transplant rejection and treating select autoimmune diseases. However, the standard oral administration of rapa results in poor...
Prodrug nanotherapy demonstrates in vivo anticryptosporidial efficacy in a mouse model of chronic Cryptosporidium infection [0.03%]
前药纳米疗法在慢性隐孢子虫感染小鼠模型中展示出体内抗隐孢子虫功效
Amalendu P Ranjan,Daniel J Czyzyk,Griselle Martinez-Traverso et al.
Amalendu P Ranjan et al.
The gastrointestinal disease cryptosporidiosis, caused by the genus Cryptosporidium, is a common cause of diarrheal diseases in children, particularly in developing countries and frequently fatal in immunocompromised individuals. Cryptospor...
Caitlin McMillan,Amy Druschitz,Stephen Rumbelow et al.
Caitlin McMillan et al.
Lipid nanoparticles (LNPs), most commonly recognised for their role in COVID-19 mRNA vaccines, are important delivery vehicles for nucleic acid (mRNA, siRNA) therapies. The physicochemical attributes, such as size, nucleic acid encapsulatio...