Dual-adjuvant mucosal vaccine leveraging mast cell and TLR9 agonists for protection against poxvirus infection [0.03%]
利用肥大细胞和TLR9激动剂的双重佐剂黏膜疫苗以防御痘病毒感染
Connor T Murphy,Grace L Williamson,Luis Ontiveros-Padilla et al.
Connor T Murphy et al.
Mast cells (MC) are innate immune cells that are predominantly localized under the skin and at mucosal surfaces, and play a role in numerous physiological processes, including host response to pathogens. Recently, mast cell activators (MCA)...
Connor T Murphy,Kristy M Ainslie
Connor T Murphy
Dengue virus (DENV) is one of the most prevalent mosquito-borne pathogens, with almost half of the global population at risk of infection. While most cases are mild, severe illness and even death is not uncommon. There are currently a lack ...
Synthesis and preliminary evaluation of cardiac imaging with [68Ga]Ga-NOTA-CTP in normal and infarcted CD1 mice [0.03%]
68镓标记NOTA-CTP在正常和心梗CD1小鼠心脏成像中的合成及其初步评价研究
Surendra Reddy Gundam,Manasa Kethamreddy,Andy González Rivera et al.
Surendra Reddy Gundam et al.
Cell-penetrating peptide-based probes for positron emission tomography (PET) are currently being developed for cardiac imaging. Herein, we have conjugated a synthetic 12 amino acids (NH2-APWHLSSQYSRT-COOH) cardiac targeting peptide (CTP) wi...
QbD product development: rapid optimization and scale-up of PBAE-based siRNA delivery via DoE-guided microfluidics [0.03%]
基于PBAE的siRNA递送的快速优化和放大：通过DoE引导的微流控技术实现
Adrian P E Kromer,Laetitia J M Eller,David C Jürgens et al.
Adrian P E Kromer et al.
Poly(β-amino ester) (PBAE)-based nanoparticles have emerged as promising carriers for RNA delivery, yet clear design rules linking formulation parameters to performance are still lacking. In this study, a Quality by Design (QbD)-guided and...
Hydrogel platforms for engineered live biotherapeutics: materials, microbial integration and clinical potential [0.03%]
用于工程活生物治疗的水凝胶平台：材料、微生物整合和临床潜力
Emma Liane Etter,Sarah Thormann,Srilekha Venkatraman et al.
Emma Liane Etter et al.
Engineered living materials (ELMs), which integrate live microorganisms into biocompatible matrices, are emerging as powerful platforms for therapeutic applications. Among these, hydrogels encapsulating engineered live biotherapeutic produc...
Effects of microparticle composition on colony morphology and viability of encapsulated therapeutic yeast for oral delivery [0.03%]
微粒组成对口服递送封装治疗性酵母菌落形态和存活率的影响
Emma Etter,Alita F Miller,Timothy Little et al.
Emma Etter et al.
Engineered live biotherapeutic products (LBPs) offer a promising avenue for targeted drug delivery, particularly within the gastrointestinal (GI) tract. Among microbial chassis, Saccharomyces cerevisiae (S. cerevisiae) is recognized as a hi...
Systematic development and optimization of a microfluidic formulation protocol for liposomal azithromycin [0.03%]
用于红霉素脂质体微流控制备的系统开发与优化方法
Abdullah A Masud,Nabilah Ibnat,Areli Medina Hernandez et al.
Abdullah A Masud et al.
Delivery of azithromycin via liposomal formulation (L-AZM) has been shown to improve the therapeutic index and activity of AZM in a preclinical model of cardiac injury, suggesting strong potential for clinical translation to treat inflammat...
Improved localized mRNA delivery using lipid nanoparticles with a novel synthetic cholesterol derivative [0.03%]
一种新型合成胆固醇衍生物的脂质纳米颗粒改进的局部化mRNA递送
Deepak K Sahel,Jonas Renner,Kseniia Yu Vlasova et al.
Deepak K Sahel et al.
Lipid nanoparticles (LNPs) are self-assembled nanocarriers made up of ionizable cationic lipids, membrane lipids, sterols, and PEGylated lipids in a predetermined proportion to encapsulate nucleic acid payloads. According to recent findings...
Systematic screening of excipients to stabilize aerosolized lipid nanoparticles for enhanced mRNA delivery [0.03%]
系统筛选辅料以稳定脂质纳米颗粒气溶胶并增强mRNA递送
Brittany J Heiser,Mae M Lewis,Meysam Mohammadi Zerankeshi et al.
Brittany J Heiser et al.
Aerosolized lipid nanoparticles (LNPs) delivering mRNA are an attractive strategy for use in local, inhalable therapy to treat patients with lung diseases. However, a major barrier to delivering aerosolized mRNA LNPs is the shear forces enc...
Breaking the cellular delivery bottleneck: recent developments in direct cytosolic delivery of biologics [0.03%]
突破细胞递送瓶颈：生物大分子胞质递送的最新研究进展
Harini Nagaraj,Victor Lehot,Nourina Nasim et al.
Harini Nagaraj et al.
Proteins and nucleic acid therapeutics represent a significant and growing share of the pharmaceutical landscape. The majority of biological and therapeutic applications of these biomolecules require access to the cytosol. Delivery of biolo...