Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease [0.03%]
蛋白质酪氨酸磷酸酶delta是STAT3磷酸酶和代谢性肝病的抑制因子
Armando Andres Roca Suarez,Frank Jühling,Julien Moehlin et al.
Armando Andres Roca Suarez et al.
Objective: Impaired hepatic expression of protein tyrosine phosphatase delta (PTPRD) is associated with increased STAT3 transcriptional activity and reduced survival from hepatocellular carcinoma in patients with chronic ...
Steatosis is not associated with increased risk of chemotherapy-associated liver injury in metastatic colorectal cancer [0.03%]
脂肪变性与转移性结直肠癌化疗相关的肝损伤增加的风险无关
Rebecca Squires,Cameron Blair,Hedvig Karteszi et al.
Rebecca Squires et al.
Bacterial dysbiosis and decrease in SCFA correlate with intestinal inflammation following alcohol intoxication and burn injury [0.03%]
酒精中毒和烧伤引起的肠道炎症与细菌生态失调及SCFAs水平下降有关
Caroline J Herrnreiter,Mary Grace Murray,Marisa Luck et al.
Caroline J Herrnreiter et al.
Background: Patients intoxicated at the time of burn experience increased rates of sepsis and death compared with that observed in similarly sized burns alone. We sought to characterise changes in the intestinal microbiom...
Functional dyspepsia and gastroparesis: are they distinct disorders, a spectrum of diseases or one disease? [0.03%]
功能性消化不良和胃轻瘫：它们是独立的疾病还是一个疾病的连续谱？
Stella-Maris Egboh,Kerith Duncanson,Michael Potter et al.
Stella-Maris Egboh et al.
Functional dyspepsia (FD) and gastroparesis (GP) are clinically managed as distinct upper gastrointestinal conditions but present with symptoms that are often indistinguishable. FD is a common disorder of gut-brain interaction that negative...
Modifiable factors for irritable bowel syndrome: evidence from Mendelian randomisation approach [0.03%]
利用孟德尔随机化方法探讨肠易激综合征的潜在改变因素
Di Liu,Meiling Cao,Shanshan Wu et al.
Di Liu et al.
Background: The potential modifiable factors influencing irritable bowel syndrome (IBS) have not been thoroughly documented. We aimed to systematically investigate the modifiable factors associated with IBS, while account...
Pathogenesis and precision medicine for predicting response in inflammatory bowel disease: advances and future directions [0.03%]
炎症性肠病的发病机制和精准医学预测响应的新进展和未来方向
Robert D Little,Thisun Jayawardana,Sabrina Koentgen et al.
Robert D Little et al.
The pathogenesis of inflammatory bowel disease (IBD) is complex and multifactorial. Undertreated disease has substantial individual and societal consequences. Current patient classification and subsequent positioning of IBD therapy are base...
Treatment of cholangiocarcinoma in patients with primary sclerosing cholangitis: a comprehensive review [0.03%]
原发性硬化性胆管炎患者胆管癌的治疗：全面回顾
Christina Villard,Carl Jorns,Annika Bergquist
Christina Villard
Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease, characterised by persistent biliary inflammation resulting in fibrosis and multifocal strictures of the biliary tree. The course of disease is highly variable, rangin...
Extracellular vesicles targeting non-parenchymal cells: the therapeutical effect on liver fibrosis [0.03%]
靶向非实质细胞的细胞外囊泡在肝纤维化治疗中的作用
Yingying Liu,Lin Wang
Yingying Liu
Liver fibrosis is the formation of a fibrous scar due to chronic liver disease including viral hepatitis, alcohol and non-alcoholic fatty liver disease. Without treatment, it will develop into cirrhosis and hepatocellular carcinoma. Up to n...
Prevalence and prediction of hepatocellular carcinoma in alcohol-associated liver disease: a retrospective study of 136 571 patients with chronic liver diseases [0.03%]
酒精性肝病患者肝细胞癌的患病率及预测因素：136571例慢性肝病患者的回顾性研究
Binxia Chang,Hui Tian,Ang Huang et al.
Binxia Chang et al.
Background and aims: To explore the incidence of alcohol-related hepatocellular carcinoma (HCC), evaluate possible synergisms between alcohol and well-known risk factors associated with HCC and establish a nomogram to pre...
ABCC2 p.R393W variant contributes to Dubin-Johnson syndrome by targeting MRP2 to proteasome degradation [0.03%]
ABCC2 p.R393W突变通过将MRP2靶向蛋白酶体降解参与Dubin-Johnson综合征发病机制
Rong-Yue Sun,Yi-Ming Chen,Mian-Mian Zhu et al.
Rong-Yue Sun et al.
Background: Dubin-Johnson syndrome (DJS), a rare autosomal recessive liver condition, is caused by biallelic loss-of-function mutations of the ABCC2 gene. This study aimed to investigate genetic variations in the drug eff...