Paul Horn,Frank Tacke
Paul Horn
The new European clinical practice guidelines from three scientific societies (European Association for the Study of the Liver, European Association for the Study of Diabetes and European Association for the Study of Obesity) on the managem...
Epigenetic mechanisms involved in hepatocellular carcinoma development and progression [0.03%]
肝细胞癌发生发展中的表观遗传调控机制研究进展
Barbara Bueloni,Maite Garcia Fernandez de Barrena,Matias Antonio Avila et al.
Barbara Bueloni et al.
Hepatocellular carcinoma (HCC) typically develops in the context of chronic liver disease, where prolonged hepatocyte exposure to inflammation drives the synergistic accumulation of genetic and epigenetic alterations. Epigenetic regulation ...
Burden of digestive system malignancies and its impact on life expectancy in China, 2004-2021 [0.03%]
中国消化系统恶性肿瘤疾病负担及其对预期寿命的影响（2004-2021年）
Ting Hu,Shiyue Wang,Yingying Wang et al.
Ting Hu et al.
Multimodal decoding of human liver regeneration uncovers novel ANXA2+ migratory hepatocytes for wound healing [0.03%]
多模态解析肝脏再生过程发现新的ANXA2阳性迁移型肝细胞促进伤口愈合
Khue Nguyen,Wen-Xing Ding,Hong-Min Ni
Khue Nguyen
Pentoxifylline use in alcohol-associated hepatitis with acute kidney injury does not improve survival: a global study [0.03%]
伴急性肾损伤的酒精性肝炎患者使用 pentoxifylline 不改善生存率：一项全球研究
Francisco Idalsoaga,Luis Antonio Diaz,Winston Dunn et al.
Francisco Idalsoaga et al.
Background: Severe alcohol-associated hepatitis (sAH) is a life-threatening condition with high mortality, where corticosteroid use is the only treatment that has shown short-term benefits. Pentoxifylline, an anti-tumour ...
Characterisation of macrophages in healthy and diseased livers in mice: identification of necrotic lesion-associated macrophages [0.03%]
小鼠健康肝脏和疾病肝脏巨噬细胞的表征：发现坏死灶相关巨噬细胞
Dechun Feng,Yukun Guan,Yang Wang et al.
Dechun Feng et al.
Background: Healthy livers contain a large number of resident macrophages named Kupffer cells (KCs), which are partially replaced by infiltrating monocyte-derived macrophages (MoMFs) during acute or chronic liver injury. ...
David Hudson,Gustavo Ayares,Zahra Taboun et al.
David Hudson et al.
Periodontal diseases are prevalent among the general population and are associated with several systemic conditions, such as chronic kidney disease and type 2 diabetes mellitus. Chronic liver disease and cirrhosis have also been linked with...
Lanlan Chen,Adrien Guillot,Carolin Victoria Schneider
Lanlan Chen
Gasdermin D deletion prevents liver injury and exacerbates extrahepatic damage in a murine model of alcohol-induced ACLF [0.03%]
Gasdermin D的缺失可预防酒精诱导的小鼠急性肝衰竭模型中的肝脏损伤并加重其肝外组织损伤
Martí Ortega-Ribera,Yuan Zhuang,Veronika Brezani et al.
Martí Ortega-Ribera et al.
Background: Gasdermin D (GSDM-D), a key executor of pyroptosis, is increased in various liver diseases and contributes to disease progression. Alcohol induces inflammasome activation and cell death, which are both linked ...
Gut cannabinoid receptor 1 regulates alcohol binge-induced intestinal permeability [0.03%]
肠道 Cannabinoid 受体 1 调节由酒精引起的肠道渗透性
Luca Maccioni,Szabolcs Dvorácskó,Grzegorz Godlewski et al.
Luca Maccioni et al.
Background: Endocannabinoids acting via cannabinoid receptor 1 (CB1R) can elicit increased intestinal permeability (a condition also called 'leaky gut'). Alcohol binge can adversely affect digestive functions, including i...