Ursodeoxycholic acid acts as an ileal FXR agonist in male mice with hepatic deficiency of FXR [0.03%]
熊去氧胆酸可作为FXR肝缺损小鼠回肠FXR激动剂
Zakiyah R Henry,Syeda Maliha,Veronia Basaly et al.
Zakiyah R Henry et al.
Background: Farnesoid X receptor (FXR) has been identified as a therapeutic target for metabolic dysfunction-associated steatohepatitis (MASH). Hepatic FXR is especially critical in suppressing liver inflammation. FXR ago...
Mucosal DNA and RNA virome alterations and their interactions with human RNA and microRNA transcriptomes in colorectal polyps [0.03%]
colorectal息肉的黏膜DNA和RNA病毒组改变及其与人类RNA和microRNA转录组相互作用
Siu Hei Shoshanna So,Wei Jiang,Yingshi Li et al.
Siu Hei Shoshanna So et al.
Background: Imbalance in the gut microbiome is known to play a role in colorectal cancer (CRC) development. Recent studies observed alterations in the faecal and mucosal DNA virome in CRC, but the role of mucosal virome i...
Gut dysbiosis is linked to severe steatosis and enhances its diagnostic performance in MASLD [0.03%]
肠道菌群失调与严重的肝脂肪变性相关，并可提高其在MASLD中的诊断性能
Marta Borges-Canha,Javier Centelles-Lodeiro,Ana Rita Leite et al.
Marta Borges-Canha et al.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease globally, with rising prevalence linked to metabolic syndrome (MetS). Excessive liver fat accumula...
Blood microbial DNA signature differentiates hepatocellular carcinoma from metastatic lesions [0.03%]
血液微生物DNA标志物区分肝细胞癌与转移病灶
Caitlin Guccione,Ana Carolina Dantas Machado,Fady Youssef et al.
Caitlin Guccione et al.
Clinical association between inflammatory bowel disease and primary sclerosing cholangitis: what changes after colectomy and liver transplantation? [0.03%]
炎症性肠病与原发性硬化性胆管炎的临床联系：结肠切除和肝脏移植后会有什么变化？
Shanshan Wang,Alisa Farokhian,Bo Shen
Shanshan Wang
Inflammatory bowel disease (IBD), particularly ulcerative colitis (UC), is associated with several hepatobiliary manifestations, most importantly primary sclerosing cholangitis (PSC). The association between these entities is bidirectional,...
New insights into liver injury and regeneration from single-cell transcriptomics [0.03%]
单细胞测序技术对肝损伤及再生的新认识
Yankai Wen,Cynthia Ju
Yankai Wen
Recent advancements in single-cell transcriptomics have significantly enhanced our understanding of acute liver injury (ALI) and regeneration. These technologies enable high-resolution profiling of individual cells, uncovering the diverse a...
Intissar Anan
Intissar Anan
This review aims to provide a comprehensive overview of the existing therapeutic options for managing neuropathic and/or cardiac manifestations associated with transthyretin amyloidosis (ATTR), along with investigational therapeutic candida...
Contribution of colibactin-producing Escherichia coli to colonic carcinogenesis [0.03%]
产colibactin大肠杆菌对结肠致癌的贡献
Hideki Ishikawa,Ryogo Aoki,Michihiro Mutoh et al.
Hideki Ishikawa et al.
Association between infection of Helicobacter pylori and the risk of reflux oesophagitis occurrence or recurrence: a systematic review and meta-analysis [0.03%]
幽门螺杆菌感染与反流性食管炎发生或复发风险关联的系统评价和meta分析
Anna Li,Yanan Zhang,Kunping Chen et al.
Anna Li et al.
Background: To investigate the correlation between infection of Helicobacter pylori (H. pylori) and the risk of reflux oesophagitis (RE) occurrence or recurrence. ...
Dietary convergence induces individual responses in faecal microbiome composition [0.03%]
饮食趋同诱导粪便菌群组成个体化响应
Astrid Vermeulen,Erik Bootsma,Sebastian Proost et al.
Astrid Vermeulen et al.
Background: Dietary variation has been identified as a key contributor to microbiome diversification. However, assessing its true impact in a cross-sectional setting is complicated by biological confounders and methodolog...