Engineering liver disease models in vitro: emerging trends and innovations [0.03%]
体外工程肝病模型：新兴趋势与创新点
Qi Rao,Lei Wang,Frank Tacke et al.
Qi Rao et al.
In vitro liver disease modelling, a rapidly evolving field, has become a multidimensional endeavour aimed at more precisely and effectively recapitulating the complexity of hepatic pathophysiology. This review systematically outlines the es...
Bin Gao,Juan Pablo Arab,Suthat Liangpunsakul et al.
Bin Gao et al.
Metabolic dysfunction and alcohol-associated liver disease (MetALD) is a recently implemented nomenclature and disease terminology for patients with metabolic dysfunction-associated steatotic liver disease, who consume greater amounts of al...
Advancements in postoperative pancreatic fistula: a comprehensive review of predictive factors, therapies, scoring systems and ongoing trials [0.03%]
术后胰漏的最新进展：预测因素、治疗、评分系统及正在进行中的临床试验的全面回顾
Pasang Sherpa,Fernando F Stancampiano,John A Stauffer et al.
Pasang Sherpa et al.
Postoperative pancreatic fistula (POPF) is a critical complication following pancreatic surgeries, marked by leakage of pancreatic fluid due to anastomotic or pancreatic duct failure. Recent advancements have refined its definition, risk cl...
Role of SQSTM1/p62 in regulating Mallory-Denk body in alcohol-associated liver disease [0.03%]
SQSTM1/p62在酒精相关性肝病中调节Mallory-Denk小体的作用
Kaitlyn Hinz,Hui Qian,Brandon Peiffer et al.
Kaitlyn Hinz et al.
Background: Alcohol-associated liver disease (ALD) is a global health problem without an effective treatment. Mallory-Denk body (MDB) is a protein aggregate commonly found in alcohol-associated hepatitis (AH). MDB primari...
Regulatory T cells in liver metastases: emerging and divergent roles in tumour progression [0.03%]
肝转移灶中的调节性T细胞：在肿瘤进展中作用的出现与分歧
Grace Wu,Ti Yang,Sepideh Gholami et al.
Grace Wu et al.
Liver metastases (LMs) pose a significant burden of morbidity and mortality, resulting in a worse prognosis for many primary malignancies. Despite advancements in cancer treatment, such as immunotherapy, molecular therapies, additional line...
Liver transplantations in Finland over 40 years: evolution and recent trends [0.03%]
芬兰40年来的肝移植：演变及最近趋势
Fredrik Åberg,Johanna Savikko,Eija Tukiainen et al.
Fredrik Åberg et al.
Background: Liver transplantation (LT) is a life-saving treatment for patients with end-stage liver disease, with significant improvements in short-term survival over the decades. However, long-term survival and trends in...
Autophagy related 14 protects against liver injury by inhibiting multiple cell death pathways [0.03%]
自噬相关蛋白14通过抑制多种细胞死亡通路保护肝脏免受损伤
Hyeong-Geug Kim,Menghao Huang,Shen Wang et al.
Hyeong-Geug Kim et al.
Background: Autophagy is critical for cellular homeostasis. Autophagy related 14 (ATG14) is a key regulator of autophagy initiation; however, its role in hepatocyte survival remains poorly understood. This study aimed to ...
Josephine Otuagomah,Alana Newcomb,Taesik Gwag et al.
Josephine Otuagomah et al.
Cluster of differentiation 47 (CD47) is a widely expressed transmembrane protein that serves as a critical immunoregulatory checkpoint in both homeostatic and pathological conditions of the digestive system. It interacts with signal regulat...
Immunotherapy against colorectal cancer via delivery of anti-PD-L1 nanobody mRNA [0.03%]
通过递送抗PD-L1纳米抗体mRNA进行结直肠癌免疫治疗
Wen-Ming Chu,Li Ma,Brian Hew et al.
Wen-Ming Chu et al.
Background: Monoclonal antibodies (mAbs) targeting immune checkpoint molecules such as programmed death ligand 1 (PD-L1), which is expressed in both immune and tumour cells, are conventional immunotherapy approaches. Alth...
Steatotic liver disease and cancer: from pathogenesis to therapeutic targets [0.03%]
脂肪变性肝病和癌症：从发病机制到治疗靶点
Zhihong Yang,Zhenjie Liu,Wanqing Liu et al.
Zhihong Yang et al.
As environmental exposomes are changing with time, so are liver diseases around the globe. Due to an increasing prevalence of overnutrition and sedentary lifestyle in the global population, metabolic dysfunction-associated steatotic liver d...