Long-term and short-term outcomes of curative-intent resection for elderly and younger patients with gallbladder carcinoma: a multicentre propensity score-matched cohort study [0.03%]
老年和年轻以治愈为目的的胆囊癌切除术患者的长期和短期结局：多中心倾向性匹配队列研究
Yu Pan,Chun-Yue Ye,Peng Zhao et al.
Yu Pan et al.
Background: While curative-intent resection for gallbladder cancer (GBC) is being increasingly performed in elderly patients, perioperative morbidity and long-term oncological outcomes in this population remain unclear. ...
Burden of metabolic dysfunction-associated steatotic liver disease in the Asia-Pacific region from 1990 to 2023 [0.03%]
1990至2023年亚太地区代谢功能障碍相关肝脂肪变病疾病负担
Xiao-Dong Zhou,Qin-Fen Chen,Giovanni Targher et al.
Xiao-Dong Zhou et al.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is an increasing health problem in the Asia-Pacific region, contributing significantly to morbidity and healthcare burden. This study provides a...
Phosphoinositide kinase PIKfyve inhibitor apilimod blocks hepatitis E virus infection [0.03%]
PIKfyve磷脂酶抑制剂apilimod可以阻断戊型肝炎病毒的感染
Julian J Ring,Sarah Schlienkamp,Maria L Goussain Darido et al.
Julian J Ring et al.
Background: Hepatitis E virus (HEV) is a leading cause of viral hepatitis, yet treatment remains limited to the off-label use of ribavirin, which can have significant side effects and is not suitable for all patients, hig...
High-dose taurine supplementation exacerbates alcohol-associated liver disease by inducing gut microbiota dysbiosis and bile acid dysregulation in mice [0.03%]
高水平牛磺酸补充通过诱导肠道微生物群失调和胆汁酸紊乱加重小鼠酒精性肝病
Jingdan Pei,Lixian Chen,Rahul Pushparaj et al.
Jingdan Pei et al.
Background: β-aminoethanesulfonic acid (taurine) is a conditionally essential amino acid that plays critical roles in bile acid (BA) conjugation, antioxidative defence and metabolic regulation. Previous studies showed th...
Exercise and dietary interventions ameliorate MASLD via the hepatic PPARγ-miR-802-Psmd2 axis [0.03%]
运动和饮食干预通过肝PPARγ-miR-802-Psmd2轴改善MASLD
Yingying Liu,Jingjing Liu,Ping Song et al.
Yingying Liu et al.
Background: MicroRNAs critically regulate metabolic dysfunction-associated steatotic liver disease (MASLD) progression and intervention. Lifestyle modifications, particularly exercise and time-restricted feeding (TRF), em...
Amyloidogenic phenotypical variation affects post-transplant outcome of hereditary transthyretin amyloidosis: a retrospective study [0.03%]
淀粉样变表型变异影响遗传性转甲状腺素蛋白淀粉样变移植术后结果：一项回顾性研究
Henryk E Wilczek,Marie Tranäng,Teresa Coelho et al.
Henryk E Wilczek et al.
Background: Liver transplantation (LTx) was once the standard of care for hereditary transthyretin amyloidosis (ATTRv), but transthyretin (TTR) stabilising and silencing therapies have supplanted it globally, partly becau...
Reduced fibre-fermenting capacity of gut microbes in multiple sclerosis may result in prebiotic dietary fibre β-fructan promoting inflammation and CNS damage [0.03%]
肠道微生物降解膳食纤维能力减弱可能导致多发性硬化患者摄入益生元膳食纤维果糖菊聚糖促炎症及中枢神经系统损伤
Stephanie L Tollenaar,Reihane Khorasaniha,Juan Jovel et al.
Stephanie L Tollenaar et al.
Background: Some people with multiple sclerosis display changes in their gut microbiota with separate evidence suggesting that symptoms may worsen following a high-fibre diet. We hypothesised that in people with multiple ...
Tao Lin,Chenhao Tong,Roman Liebe et al.
Tao Lin et al.
Massive hepatic necrosis (MHN), characterised by extensive loss of hepatocytes, represents the most severe pathological lesion in acute liver failure (ALF). MHN-associated ALF primarily occurs in patients with acute viral hepatitis A, B or ...
Correction: Regulatory T cells in liver metastases: emerging and divergent roles in tumour progression [0.03%]
纠正：肝转移灶中的调节性T细胞：在肿瘤进展中出现和分歧的作用
[This corrects the article DOI: 10.1136/egastro-2025-100257.]. Copyright © Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No co...
Published Erratum
eGastroenterology. 2026 Jan 12;4(1):e100257corr1. DOI:10.1136/egastro-2025-100257corr1 2026
Application of machine learning in the discovery of antimicrobial peptides: exploring their potential for ulcerative colitis therapy [0.03%]
机器学习在抗菌肽发现中的应用及抗菌肽治疗溃疡性结肠炎的潜力探索
Hui Miao,Ziwei Wang,Shihu Chen et al.
Hui Miao et al.
Background: Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease with complex aetiology and limited treatment options. Antimicrobial peptides (AMPs), as endogenous immune effectors, have recently eme...