Bile acids regulation of cellular stress responses in liver physiology and diseases [0.03%]
胆酸调节细胞压力反应在肝脏生理和疾病中的作用
Tiangang Li,Mohammad Nazmul Hasan,Lijie Gu
Tiangang Li
Bile acids are physiological detergents and signalling molecules that are critically implicated in liver health and diseases. Dysregulation of bile acid homeostasis alters cell function and causes cell injury in chronic liver diseases. Ther...
Environmental PM2.5-triggered stress responses in digestive diseases [0.03%]
环境PM2.5诱发的消化系统疾病应力响应机制研究进展
Kezhong Zhang
Kezhong Zhang
Airborne particulate matter in fine and ultrafine ranges (aerodynamic diameter less than 2.5 μm, PM2.5) is a primary air pollutant that poses a serious threat to public health. Accumulating evidence has pointed to a close association betwe...
Wen-Xing Ding,Xiaowen Ma,Sydney Kim et al.
Wen-Xing Ding et al.
Acute pancreatitis is a common inflammatory gastrointestinal disease without any successful treatment. Pancreatic exocrine acinar cells have high rates of protein synthesis to produce and secrete large amounts of digestive enzymes. When the...
Perspectives of mitochondria-lysosome-related organelle in hepatocyte dedifferentiation and implications in chronic liver disease [0.03%]
肝细胞去分化的线粒体溶酶体相关器官颗粒的视角及其在慢性肝病中的意义
Xiaowen Ma,Hong-Min Ni,Wen-Xing Ding
Xiaowen Ma
Incorporating biological and clinical insights into variant choice for Mendelian randomisation: examples and principles [0.03%]
将生物学和临床见解融入孟德尔随机化中的变异选择：示例和原则
Stephen Burgess,Héléne Toinét Cronjé
Stephen Burgess
Mendelian randomisation is an accessible and valuable epidemiological approach to provide insight into the causal nature of relationships between risk factor exposures and disease outcomes. However, if performed without critical thought, we...
Revolutionary transformation lowering the mortality of pancreaticoduodenectomy: a historical review [0.03%]
降低胰十二指肠切除术死亡率的革命性转变的历史回顾
Bo Chang Wu,Jakub Wlodarczyk,Sanaz Nourmohammadi Abadchi et al.
Bo Chang Wu et al.
The History Maker paper focuses on the extraordinary revolution that dramatically improved the surgical results for the Whipple procedure (pancreaticoduodenectomy) in the 1980s and identifies Dr. Cameron as the leader of this revolution, wh...
Pioneering use of genetic analysis for CDH1 to identify candidates for prophylactic total gastrectomy to prevent hereditary diffuse gastric cancer [0.03%]
利用基因分析识别遗传性弥漫型胃癌预防性全胃切除术的手术适应症中的创新应用研究
Farzad Mokhtari-Esbuie,Bryan Szeglin,Mohsen Rouhani Ravari et al.
Farzad Mokhtari-Esbuie et al.
Worldwide, gastric cancer results in significant morbidity and mortality. Ten per cent of patients with gastric cancer have a strong family history of the disease. CDH1 (E-cadherin) has been identified as a key gene whose mutation leads to ...
Recent insights into the pathogenesis and therapeutic targets of chronic liver diseases [0.03%]
慢性肝病发病机制和治疗靶点研究的新见解
Yankai Wen,Lichun Ma,Cynthia Ju
Yankai Wen
Viral hepatitis, alcohol-associated liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are the three major causes of chronic liver diseases, which account for approximately 2 million deaths per year worldwide. The current dir...
Wajahat Mehal
Wajahat Mehal
The understanding of the mechanisms of liver fibrosis has been dominated by models in which chronic hepatocellular injury is the initiating step as is seen with viral infections. The increased prevalence of the metabolic syndrome, and the i...
Luca Maccioni,Yaojie Fu,Yves Horsmans et al.
Luca Maccioni et al.
Excessive alcohol drinking can cause pathological changes including carcinogenesis in the digestive tract from mouth to large intestine, but the underlying mechanisms are not fully understood. In this review, we discuss the effects of alcoh...