MiR-92a-3p Knockdown Attenuates Transforming Growth Factor-β1-induced Tubulointerstitial Fibrosis by Targeting LIN28A-mediated EMT Pathway [0.03%]
miR-92a-3p敲低通过靶向LIN28A介导的EMT通路减弱转化生长因子-β1诱导的肾间质纤维化
Mingzhi Xu,Mingjiao Pang,Chunli Wang et al.
Mingzhi Xu et al.
The role of microRNAs in regulating tubulointerstitial fibrosis, a key feature of progressive chronic kidney disease, is of significant importance. LIN28A has been reported to attenuate renal fibrosis in obstructive nephropathy. Here, our o...
Interference with Histone Deacetylase 4 Regulates c-Jun N-terminal Kinase/Activating Protein-1 Signaling to Ameliorate Sepsis-induced Alveolar Epithelial Cell Injury [0.03%]
干扰组蛋白去乙酰酶4调节c-Jun氨基末端激酶/激活蛋白-1信号通路以缓解内毒素致肺泡上皮细胞损伤
Qunyan Chen,Jiachang Lao
Qunyan Chen
Sepsis is a syndrome of systemic inflammatory response resulting from infection, which can lead to severe lung injury. Histone deacetylase 4 (HDAC4) is a key protein known to regulate a wide range of cellular processes. This study was desig...
MicroRNA-150-5p-mediated Inhibition of Cell Proliferation, G1/S Transition, and Migration in Bladder Cancer through Targeting NEDD4-binding Protein 2-like 1 Gene [0.03%]
microRNA-150-5p通过靶向nedd4结合蛋白2样1基因抑制膀胱癌细胞增殖、G1/S期转换和迁移
Pinlang Rao,Jianmin Li,Junhui Xiong et al.
Pinlang Rao et al.
MicroRNA-150-5p (miR-150-5p) has been implicated in the progression of several cancer types, yet its specific functional role and regulatory mechanisms in bladder cancer (BC) remain largely unexplored. Our study revealed significant downreg...
The Effect of High- and Low-power Holmium Laser Settings for Transurethral Lithotripsy in the Management of Adults with Ureteral Stone [0.03%]
高能量和低能量钬激光设置在输尿管结石治疗中的疗效分析
Yuhuan Wang,Jun Wang,Xiaoping Sun
Yuhuan Wang
Since there is insufficient evidence to determine the best treatment of transurethral laser lithotripsy (TLL) in ureteral stones, this study compared the effectiveness and safety of TLL using high-power (HP) (100 W) and low-power (LP) (20 W...
Protective Effects of Trans-Chalcone on Myocardial Ischemia and Reperfusion Challenge through Targeting Phosphoinositide 3-kinase/Akt-inflammosome Interaction [0.03%]
茋查儿康因通过靶向磷脂酰肌醇3-激酶/蛋白激酶A-k inflammosome相互作用对抗心肌缺血/复氧损伤的作用及机制研究
Jing Wang,Shaik Althaf Hussain,Narendra Maddu et al.
Jing Wang et al.
Ischemia-reperfusion (IR) injury remains a pivotal contributor to myocardial damage following acute coronary events and revascularization procedures. Phosphoinositide 3-kinase (PI3K), a key mediator of cell survival signaling, plays a centr...
Cinnamaldehyde, A Bioactive Compound from the Leaves of Cinnamomum osmophloeum Kaneh, Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice by Inhibiting the NLRP3 Inflammasome [0.03%]
肉桂酸化合物柳葉桂皮醛通过抑制NLRP3炎性小体改善DSS诱导的小鼠结肠炎
May-Lan Liu,Wei-Ting Wong,Yih-Ming Weng et al.
May-Lan Liu et al.
Inflammatory bowel disease (IBD) comprises a group of idiopathic intestinal disorders, including ulcerative colitis and Crohn's disease, significantly impacting the quality of life for affected individuals. The effective management of these...
Perturbations of Telmisartan Alone and in Combination with Ranolazineor Dapagliflozin on the Amplitude and Gating of Voltage-gated Na + Current in Neuroblastoma Neuronal Cells [0.03%]
坎地沙坦单独及联合达格列净和 ranolazine对神经母细胞瘤神经元电压门控钠离子电流振幅及失活的影响研究
Yi-Jung Chen,Chien-Ching Lee,Edmund Cheung So
Yi-Jung Chen
A recent study investigated the correlation between telmisartan (TEL) exposure and Alzheimer's disease (AD) risk among African Americans (AAs) and European Americans. Their findings indicated that moderate-to-high TEL exposure was linked to...
Protective Effect of Curcumin on the Tight Junction Integrity and Cellular Senescence in Human Retinal Pigment Epithelium of Early Diabetic Retinopathy [0.03%]
姜黄素对糖尿病视网膜病变患者人视网膜色素上皮细胞紧密连接的保护作用及对细胞衰老的影响
Yu-Wen Cheng,Ya-Chih Huang,Kai-Fu Chang et al.
Yu-Wen Cheng et al.
Diabetic retinopathy (DR) is a secondary complication of diabetes that can lead to visual impairment and blindness. The retinal pigment epithelium (RPE) is a monolayer of pigment cells that forms the blood-retinal barrier (BRB) via tight ju...
Buyang Huanwu Decoction Alleviates Atherosclerosis by Regulating gut Microbiome and Metabolites in Apolipoprotein E-deficient Mice fed with High-fat Diet [0.03%]
补阳还五汤通过调节肠道菌群和代谢产物改善高脂饮食Apoe基因敲除小鼠动脉粥样硬化病变进展
Qun Yu,Yilin Zhang,Wenyun Zeng et al.
Qun Yu et al.
The traditional Chinese herbal prescription Buyang Huanwu decoction (BHD), effectively treats atherosclerosis. However, the mechanism of BHD in atherosclerosis remains unclear. We aimed to determine whether BHD could alleviate atheroscleros...
The Anti-Atherosclerotic Effects of Buyang Huanwu Decoction through M1 and M2 Macrophage Polarization in an ApoE Knockout Mouse Model [0.03%]
基于载脂蛋白E基因敲除小鼠模型的补阳还五汤抗动脉粥样硬化作用及其通过M1和M2型巨噬细胞极化实现机制研究
Mengjiao Ji,Lei Mao,Yanan Wei et al.
Mengjiao Ji et al.
Arteriosclerosis (AS) is a chronic inflammatory disease and Buyang Huanwu decoction (BHD) has been identified as an anti-atherosclerosis effect, and the study is aimed to investigate the underlying mechanism. The E4 allele of Apolipoprotein...