Elevations of N-Terminal Mid-Fragment of Osteocalcin and Cystatin C Levels are Associated with Disorders of Glycolipid Metabolism and Abnormal Bone Metabolism in Patients with Type 2 Diabetes Mellitus Complicated with Osteoporosis [0.03%]
骨代谢异常的2型糖尿病合并骨质疏松患者Ⅰ型胶原C端肽、骨钙素N端中分子量片段和胱抑素C水平的变化及其临床意义
Xiaofang Guo,Yun Shen,Teng Du et al.
Xiaofang Guo et al.
Type 2 diabetes mellitus (T2DM) patients always develop osteoporosis (OP). We examined correlations of N-terminal mid-fragment of osteocalcin (N-MID) and cystatin C (Cys C) levels with glycolipid metabolism, bone metabolism markers, and bon...
Pu-Yeh Wu,Cheng-Chang Lien
Pu-Yeh Wu
Interstitial pH fluctuations occur normally in the brain and significantly modulate neuronal functions. Acid-sensing ion channels (ASICs), which serve as neuronal acid chemosensors, play important roles in synaptic plasticity, learning, and...
The Impact of Different Muscle Relaxation Techniques on the Upper Trapezius and Its Relationship with the Middle Trapezius [0.03%]
不同肌筋膜放松技术对上斜方肌的影响及其与中斜方肌的关联性研究
Gao Li,Dan Liu,Di Yang et al.
Gao Li et al.
The relaxation of trapezius muscles is widely believed to alleviate fatigue or injury of the trapezius muscles and reduce the risk of shoulder and neck pain. This study aims to examine the effects of different muscle relaxation techniques o...
Randomized Controlled Trial
Journal of physiological investigation. 2024 Jul 1;67(4):225-232. DOI:10.4103/ejpi.EJPI-D-24-00041 2024
Allicin Mitigates Diabetic Retinopathy in Rats by Activating Phosphatase and Tensin Homolog-induced Kinase 1/Parkin-mitophagy and Inhibiting Oxidative Stress-mediated NOD-like Receptor Family Pyrin Domain Containing 3 Inflammasome [0.03%]
大蒜素通过激活PTEN诱导的激酶1/Parkin线粒体自噬和抑制NLRP3炎性小体相关氧化应激减轻糖尿病大鼠视网膜病变
Yuanyuan Xu,Jia Yu
Yuanyuan Xu
Diabetic retinopathy (DR) is one of the significant disabling outcomes of diabetes mellitus characterized by retinal microvascular damage, inflammation, and neuronal dysfunction. Allicin (Alc), a natural compound found in garlic, has garner...
Purine-rich Element-binding Protein B Mediates Ferroptosis in Lipopolysaccharide-induced Raw264.7 Macrophage Inflammation [0.03%]
富嘌呤元件结合蛋白B介导脂多糖诱导的RAW264.7巨噬细胞炎症中的铁死亡
Zhaosi Wang,Wei Zhang,Xiangrui Zhu et al.
Zhaosi Wang et al.
Lipopolysaccharide (LPS) plays an important role in Raw264.7 macrophage ferroptosis and inflammation. Purine-rich element-binding protein B (Purb) influences cellular processes by regulating gene expression as a transcription factor. Howeve...
Functional Role of DDR1 in Oligodendrocyte Signaling Mechanism in Association with Myelination and Remyelination Process in the Central Nerve System [0.03%]
DDR1在中枢神经系统髓鞘和再髓鞘过程中的功能作用及在少突胶质细胞信号机制中的作用
Mariadoss Arokia Vijaya Anand,Kumar Shivamadhaiah Manjula,Chau-Zen Wang
Mariadoss Arokia Vijaya Anand
Multiple sclerosis (MS) is a complicated, inflammatory disease that causes demyelination of the central nervous system (CNS), resulting in a variety of neurological abnormalities. Over the past several decades, different animal models have ...
The Impact of Highly Selective Thoracic Sympathectomy on the Progression of Monocrotaline-induced Pulmonary Arterial Hypertension in Rats [0.03%]
胸交感神经离断术对肺动脉高压大鼠疾病进展影响的实验研究
Wuqianhui Liu,Chen Men,Zibo Liu et al.
Wuqianhui Liu et al.
Pulmonary arterial hypertension (PAH) is characterized by persistently elevated pulmonary artery pressure and vascular resistance. Sympathetic overactivity in hypertension participates in pulmonary vascular remodeling and heart failure. The...
MiR-92a-3p Knockdown Attenuates Transforming Growth Factor-β1-induced Tubulointerstitial Fibrosis by Targeting LIN28A-mediated EMT Pathway [0.03%]
miR-92a-3p敲低通过靶向LIN28A介导的EMT通路减弱转化生长因子-β1诱导的肾间质纤维化
Mingzhi Xu,Mingjiao Pang,Chunli Wang et al.
Mingzhi Xu et al.
The role of microRNAs in regulating tubulointerstitial fibrosis, a key feature of progressive chronic kidney disease, is of significant importance. LIN28A has been reported to attenuate renal fibrosis in obstructive nephropathy. Here, our o...
Interference with Histone Deacetylase 4 Regulates c-Jun N-terminal Kinase/Activating Protein-1 Signaling to Ameliorate Sepsis-induced Alveolar Epithelial Cell Injury [0.03%]
干扰组蛋白去乙酰酶4调节c-Jun氨基末端激酶/激活蛋白-1信号通路以缓解内毒素致肺泡上皮细胞损伤
Qunyan Chen,Jiachang Lao
Qunyan Chen
Sepsis is a syndrome of systemic inflammatory response resulting from infection, which can lead to severe lung injury. Histone deacetylase 4 (HDAC4) is a key protein known to regulate a wide range of cellular processes. This study was desig...
MicroRNA-150-5p-mediated Inhibition of Cell Proliferation, G1/S Transition, and Migration in Bladder Cancer through Targeting NEDD4-binding Protein 2-like 1 Gene [0.03%]
microRNA-150-5p通过靶向nedd4结合蛋白2样1基因抑制膀胱癌细胞增殖、G1/S期转换和迁移
Pinlang Rao,Jianmin Li,Junhui Xiong et al.
Pinlang Rao et al.
MicroRNA-150-5p (miR-150-5p) has been implicated in the progression of several cancer types, yet its specific functional role and regulatory mechanisms in bladder cancer (BC) remain largely unexplored. Our study revealed significant downreg...