Effect of Advillin Knockout on Diabetic Neuropathy Induced by Multiple Low Doses of Streptozotocin [0.03%]
Advillin基因敲除对多次小剂量链脲佐菌素诱导的糖尿病周围神经病变的影响
Yu-Chia Chuang,Bo-Yang Jiang,Chih-Cheng Chen
Yu-Chia Chuang
Advillin is an actin-binding protein involved in regulating the organization of actin filaments and the dynamics of axonal growth cones. In mice, advillin is exclusively expressed in somatosensory neurons, ubiquitously expressed in all neur...
Neuroprotective Role of Transchalcone in Parkinson's Disease through AMP-activated Protein Kinase-mediated Signaling Pathway [0.03%]
茋查尔酮通过AMP活化蛋白激酶介导的信号通路在帕金森病中的神经保护作用
Yao Cheng,Shaik Althaf Hussain,Turki Mayudh Alrubie et al.
Yao Cheng et al.
Parkinson's disease (PD) is a gradually worsening neurodegenerative condition marked by the deterioration of dopaminergic neurons, motor dysfunction, and mitochondrial dysfunction. Trans-chalcone, a natural flavonoid, has shown promise in v...
Exploring the Effects of Tomatidine ((3β, 5α, 22β, and 25β)-Spirosolan-3-ol) on Voltage-gated Na+ currents: Insights Into Its Ionic Mechanisms of Action on Current Magnitude, Gating, and Frequency Dependence [0.03%]
番茄胺((3β, 5α, 22β, 和 25β)- Spirosolan-3-ol)对电压门控Na+电流的影响：关于其离子作用机制的见解，包括对电流幅度、闸门和频率依赖性的影响
Tso-Lin Lin,Edmund Cheung So,Sheng-Nan Wu
Tso-Lin Lin
Tomatidine, a major tomato glycoalkaloid, is effective for the prevention of skeletal muscle wasting and enhancing mitophagy. However, its effects on transmembrane ionic currents are not well explored. In this study, we explored the interac...
A Multi-ingredient Supplement Reduced Markers of Muscle Damage after a Rugby Match in Collegiate Male Players [0.03%]
一种多成分补充剂可减少大学生男子橄榄球队运动员比赛后的肌肉损伤标志物
Chang-Li Hsueh,Wang-Shiang Huang,Chen-Kang Chang
Chang-Li Hsueh
Eccentric exercise and collisions that lead to muscle damage are common place among athletes. This study aimed to investigate the effect of a multi-ingredient supplement (MIS), containing the extracts of turmeric, chicken meat, and apple an...
Randomized Controlled Trial
Journal of physiological investigation. 2024 Nov 1;67(6):293-297. DOI:10.4103/ejpi.EJPI-D-24-00074 2024
Leptin Promotes the Expression of Pro-inflammatory Mediator Genes but Does Not Alter Osteoclastogenesis and Early Stage Differentiation of Osteoblasts [0.03%]
瘦素促进促炎症介质基因的表达但不影响破骨细胞生成及成骨细胞早期分化
Chien-Ning Hsu,Chih-Hong Kao,Chin-Hua Yang et al.
Chien-Ning Hsu et al.
Leptin, a hormone secreted by adipose tissue, plays a pivotal role in maintaining energy metabolism and bone quality. Dysregulation of leptin can lead to the development of various pathological conditions. For example, the concentration of ...
The Promising Key Factors Mediating Secondary Neuronal Damage in the Perihematomal Region of Intracerebellar Hemorrhage of Mice [0.03%]
有关小鼠脑室内出血后红核周围组织二次损伤的若干关键因素研究
Saandeep Bhatia,Ramissh Paramasivam,Mohd Khairul Izamil Bin Zolkefley et al.
Saandeep Bhatia et al.
The underlying mechanisms of secondary neuronal damage following intracerebellar hemorrhage (ICbH) have not yet been clearly understood. Our previous study reported apoptotic neuronal damage in the perihematomal region (PH) in mice. However...
Association between Regular Exercise and Urinary Uric Acid Excretion in Chinese Adults: A Cross-sectional Study [0.03%]
中国成年人经常锻炼与尿酸排泄关系的横断面研究
Wenjuan Wang,Xiaoying Zhou,Yu Liu et al.
Wenjuan Wang et al.
Regular exercise decreases the risk of hyperuricemia, which is related to reduced urinary uric acid excretion (UUA/UAE). However, few studies have assessed the association between regular exercise and UAE. We conducted this study to investi...
Zhenbao Pill Attenuates Microglia Activation to Improve Spinal Cord Injury via miR-214-5p/SOX4/β-catenin Axis [0.03%]
镇脑宁胶囊通过miR-214-5p/SOX4/β-catenin轴抑制小胶质细胞活化改善脊髓损伤
Yanqiang Huan,Juan He,Pengfei Li et al.
Yanqiang Huan et al.
Zhenbao pill (ZBP) has been shown to improve outcomes in spinal cord injury (SCI). However, its potential regulatory mechanisms in SCI remain to be elucidated. This study aimed to define the role of ZBP and its underlying molecular mechanis...
Chronic Restraint Stress Did Not Alter Active Avoidance Coping or Neuronal Activation Levels of the Medial Prefrontal Cortex or the Nucleus Accumbens in Male Rats [0.03%]
慢性束缚压力不影响雄性大鼠前额叶皮层和伏隔核的主动回避应对或神经元激活水平
Hsun-Yi Kuan,Chun-Hui Chang
Hsun-Yi Kuan
Stress is an adaptive response crucial for survival. However, chronic stress can lead to maladaptive behaviors and health issues. Prolonged stress reduces the flexibility of defensive coping behaviors. Previous studies have shown that the m...
Morpho-physiological Diversity of Cholecystokinin-expressing Interneurons in the Dentate Gyrus [0.03%]
海马齿状回胆囊收缩素阳性中间神经元的形态生理多样性研究
Yu-Jui Li,Chia-Wei Yeh,Wahab Imam Abdulmajeed et al.
Yu-Jui Li et al.
The hippocampus plays a crucial role in learning, memory, and emotion, with the dentate gyrus (DG) serving as the primary gateway. The DG receives multimodal sensory inputs from outside the hippocampus and relays this integrated information...