MiR-99 Family of Exosomes Targets Myotubularin-related Protein 3 to Regulate Autophagy in Trophoblast Cells and Influence Insulin Resistance [0.03%]
微小RNA-99家族通过靶向肌管相关蛋白3调节滋养细胞自噬及影响胰岛素抵抗
Shao-Xiao Liu,Yang Lv
Shao-Xiao Liu
The global incidence of gestational diabetes mellitus (GDM) continues to rise and is associated with negative outcomes in pregnancy. This study aims to investigate how the miR-99 family of exosomes derived from the placenta targets myotubul...
MiR-367-3p Alleviates Oxidative Stress Injury in the Ischemia/Reperfusion Injury Cell Model by Targeting Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4-mediated Keap1/Nrf2/ARE Pathway [0.03%]
miR-367-3p通过靶向烟酰胺腺嘌呤二核苷酸磷酸氧化酶4介导的Keap1/Nrf2/ARE途径缓解缺血再灌注损伤细胞模型中的氧化应激损伤
Qian He,Xingwen Tian,Yujie Zhang et al.
Qian He et al.
Ischemic stroke is a debilitating central nervous disease linked to oxidative stress. Although miR-367-3p has been reported to be related to ischemic stroke, the direct evidence concerning oxidative stress remains elusive. Our study aimed t...
Extracts of Chuanxiong and Baizhi Attenuate Neuroinflammation in Chronic Migraine Rats by Inhibiting TLR4/MyD88/Nuclear Factor Kappa B Signal Pathway [0.03%]
川芎白芷 extracts通过抑制TLR4/MyD88核因子κB信号途径减轻慢性偏头痛模型大鼠的神经炎症反应
Xin Li,Ting Du,Fan Yang et al.
Xin Li et al.
This study investigates the mechanism by which a compound mixture of Chuanxiong and Baizhi (CMCB) modulates the TLR4/MyD88/nuclear factor kappa B (NF-κB) pathway to alleviate neuroinflammation in nitroglycerin (NTG)-induced chronic migrain...
Structural and Functional Changes of the Heart in Young Adult Tennis Players [0.03%]
青年网球运动员的心脏结构和功能变化
Hsu-Chun Huang,Wei-Ting Lin,Ruei-Shyang Liu et al.
Hsu-Chun Huang et al.
This cross-sectional observational study investigated undetermined cardiac remodeling and functional adaptation in young tennis players. Fourteen males with regular tennis training (at least three times a week, mean playing age 8.3 ± 3.8 y...
Impact of Transchalcone on Neurological Outcomes in Cerebral Ischemia-reperfusion Injury in Rat: Role of AMP-activated Protein Kinase-mitochondrial Signaling Pathways [0.03%]
transcalcone对脑缺血再灌注损伤大鼠神经功能结局的影响及AMPK线粒体信号通路的作用机制
Xiuyun Xue,Jingjing Du,Shaik Althaf Hussain et al.
Xiuyun Xue et al.
Cerebral ischemia-reperfusion (CIR) injury results in significant secondary brain damage after ischemic stroke due to oxidative stress, mitochondrial dysfunction, and neuroinflammation. Transchalcone (TCH), a polyphenolic compound, exhibits...
Mechanism of Action of Exercise in Regulating Spontaneous Hypertension through the Janus Kinase 2/Signal Transducer and Activator of Transcription 3 Signaling Pathway [0.03%]
运动通过Janus激酶2/信号转导及转录激活因子3信号通路调节自发性高血压大鼠的作用机制研究
Yu Li,Xiaoju Song,Lianjing Dai et al.
Yu Li et al.
Although blood pressure can be regulated to normal levels through drug intervention, the prognosis for patients remains bleak, and there is an urgent need to find a new way to prevent or reverse hypertension and its adverse consequences. So...
MiR-455-5p Mitigates Interleukin-1 β-induced Chondrocyte Damage Linked to Osteoarthritis by Targeting TNFAIP8 [0.03%]
microRNA-455-5p通过靶向TNFAIP8缓解与骨关节炎相关的白细胞介素-1β诱导的软骨细胞损伤
Tao Zhang,Wei Wang,Jinlei Sun et al.
Tao Zhang et al.
MicroRNAs have been extensively implicated in osteoarthritis (OA) progression. Our study aims to investigate the impact of miR-455-5p on OA progression and related molecular mechanisms. Cartilage tissues were collected from patients with OA...
Hydrogen Sulfide Inhibits Ferritinophagy-Mediated Ferroptosis in the Hippocampus of Rotenone-Exposed Rats [0.03%]
氢硫化物通过抑制罗藤酮处理大鼠海马中的Ferroptosis(铁死亡)来保护神经细胞
Xi Chen,Li Liu,Wu Jiang et al.
Xi Chen et al.
Our previous research has established that hydrogen sulfide (H2S) exerts an antagonistic effect against the hippocampal neurotoxicity induced by Rotenone (ROT). However, the underlying mechanisms are so far poorly understood. Substantial ev...
The Role of Acupuncture of 13 Ghost Points Combined with Cognitive Therapy in Alleviating Liver-qi Stagnation Depression: A Clinical Study [0.03%]
针刺十三鬼穴配合认知疗法对肝气郁结型抑郁的临床研究作用观察
Xiaojian Yin,Xianyong Wang
Xiaojian Yin
Liver-qi stagnation-type depression, marked by irritability and emotional imbalance, often responds inadequately to medication alone. This study explored the efficacy of combining acupuncture at the 13 ghost points with cognitive therapy fo...
Candida tropicalis Alters Barrier Permeability and Claudin-1 Organization in Intestinal Epithelial Cells [0.03%]
卡氏肺孢菌改变肠道上皮细胞屏障通透性及闭合蛋白-1排列
Ha The Doan,Yi-Ling Chiu,Li-Chieh Cheng et al.
Ha The Doan et al.
Inflammatory bowel disease (IBD) is an autoimmune disorder characterized by chronic inflammation of the gut and compromised intestinal barrier function, resulting from aberrant immune responses targeting the intestinal microbiota. While the...