Remy Boisgard,Patrick Chames,Brigitte Kerfelec
Remy Boisgard
Due to its restricted expression in normal tissues, its frequent overexpression in various aggressive malignancies, and its involvement in several pro-tumorigenic signaling pathways, mesothelin, a glycosylphosphatidylinositol-anchored cell ...
Nilay Shah
Nilay Shah
The treatment of cancers was revolutionized by the use of combination "conventional" chemotherapy, first in children, during the 20th century. That foundation of therapy, while having achieved significant advances in survival, has reached i...
A CRISPR-Cas13d cancer therapeutic enables selective elimination of uveal melanoma [0.03%]
一种CRISPR-Cas13d癌症疗法能够选择性地消除眼内黑色素瘤
Daniel Stauber,Lucas Sosnick,Yitong Ma et al.
Daniel Stauber et al.
Uveal melanoma, the most common eye cancer in adults, remains limited to surgical intervention and radiotherapy, with a dismal survival rate that has not improved in over 50 years. To address this therapeutic impasse, we systematically anal...
Identification of small molecules that enhance aminoglycoside-mediated suppression of CFTR and NF1 nonsense mutations [0.03%]
用于增强抗生素介导的囊性纤维化跨膜传导调节器和NF1终止密码子突变抑制的小分子鉴定
Joshua Sammons,Jianguo Chen,Kari Thrasher et al.
Joshua Sammons et al.
Nonsense suppression rescues functional protein from mRNAs containing in-frame premature termination codons (PTCs). This approach employs small molecules that promote insertion of tRNAs at a PTC during translation (called "readthrough"), en...
CBX6-CA9 axis: An epigenetic-metabolic vulnerability in glioblastoma [0.03%]
CBX6-CA9轴：胶质母细胞瘤中的表观遗传-代谢弱点
Keykavous Parang
Keykavous Parang
Hyatt Balke-Want,Vimal Keerthi,Steven A Feldman
Hyatt Balke-Want
Targeted attack: Harnessing myelin-specific plasmolipin for suppression of neuroblastoma and glioblastoma [0.03%]
靶向攻击：利用髓鞘特异性血影蛋白酶抑制神经母细胞瘤和胶质母细胞瘤
Pavel Spirin,Andrey Shulgin,Timofey Lebedev et al.
Pavel Spirin et al.
There is a growing urgency to develop effective strategies for studying and targeting glioblastoma including, which are crucial for tumor initiation and resistance to therapy. Human-immunodeficiency-virus-type-1-based viral particles have e...
CBX6 and CA9 as predictive indicators and therapeutic targets in GBM [0.03%]
CBX6和CA9在胶质母细胞瘤中的预测指标及治疗靶点作用
Yujun Wang,Yongsheng Jia,Yate-Ching Yuan et al.
Yujun Wang et al.
Glioblastoma (GBM) is an aggressive primary brain tumor that, partly due to its hypoxic tumor microenvironment (TME), is extremely difficult to treat. In our study, RNA sequencing and quantitative reverse-transcription PCR (qRT-PCR) analysi...
Vinorelbine enhances the efficacy of oncolytic vaccinia virus in a preclinical model of ovarian high-grade serous carcinoma [0.03%]
长春地辛增效溶瘤痘苗病毒治疗卵巢高级别浆液性癌的疗效：前期研究模型结果显示
Stephanie Drymiotou,Christophe J Queval,Katherine E Tyson et al.
Stephanie Drymiotou et al.
Vaccinia virus, known for its clinical safety, has a tropism for primary and metastatic tumors as well as ovarian tissue. Consequently, oncolytic approaches with recombinant vaccinia viruses have emerged as attractive agents against ovarian...
Differential immune infiltrates in histomorphologic Wilms tumor regions identify prognostic macrophages [0.03%]
不同免疫浸润在组织形态学生韦尔姆斯瘤区域中确定有预后的巨噬细胞
Lukas Watzke,Francesca Palmisani,Maud Plaschka et al.
Lukas Watzke et al.
Wilms tumor (WT) is characterized by a unique ternary histology, including blastemal, epithelial, and mesenchymal elements. Although overall survival is high, relapse and metastasis affect not only high-risk but also intermediate-risk (IR) ...