CAR-T cells directed toward PD-L1 demonstrate potent, antigen-specific activity against cholangiocarcinoma: A proof of concept study [0.03%]
针对PD-L1的CAR-T细胞在胆管癌中展现强有力的抗原特异性活性：概念验证研究
Piyush Gondaliya,Yan Luo,Adil Ali Sayyed et al.
Piyush Gondaliya et al.
An immunosuppressive microenvironment driven by tumor and stromal cells expressing programmed death-ligand 1 (PD-L1) contributes to immune evasion and poor prognosis in cholangiocarcinoma. Although antibodies to PD-L1 are used clinically, t...
RNA-based precision medicine in glioblastoma driven by oncogenic gene fusions [0.03%]
致癌基因融合驱动的胶质母细胞瘤的RNA精准医疗
Maël Bouillon,Clémentine Lapoujade,Laëtitia Basset et al.
Maël Bouillon et al.
Glioblastoma, the most common primary central nervous system tumor, is the leading cause of death in neuro-oncology. Gene fusions, caused by chromosomal rearrangements, may act as drivers of tumorigenesis in glioblastoma. These fusions resu...
AAV transduction of human glioblastoma cell lines induces perturbation in cell proliferation [0.03%]
人胶质母细胞瘤细胞系的AAV转导会影响细胞增殖
Angela Wu,Carina J Dumo,William H Cook et al.
Angela Wu et al.
Glioblastoma (GBM) is a highly aggressive type of brain cancer associated with poor prognosis due to limited effective treatment options. Adeno-associated viral (AAV) vector-based gene therapy strategies have demonstrated promise in preclin...
Boosting CAR T cell functionality with oncolytic viruses for the treatment of pediatric diffuse midline gliomas [0.03%]
利用溶瘤病毒增强CAR-T细胞功能以治疗儿童弥漫性中线胶质瘤
Konstantinos Vazaios,Antonio C Tallon-Cobos,Louisa P J van Oosterhout et al.
Konstantinos Vazaios et al.
Despite the success of CAR (chimeric antigen receptor) T cells in hematological malignancies, their effectiveness against solid or brain tumors, such as pediatric diffuse midline gliomas (DMGs), is limited. CAR T cell success is hampered by...
Overcoming disease refractoriness through CD7-targeting CAR T cells in acute myeloid leukemia [0.03%]
针对急性髓系白血病疾病抵抗性的CD7导向的CAR-T细胞疗法
Marco Becilli,Franco Locatelli
Marco Becilli
Targeting intrinsic apoptosis rewires human NK cell persistence: NOXA as a dominant survival switch [0.03%]
靶向细胞固有的凋亡过程可重塑人类NK细胞的持久性：NOXA作为主要的生存开关
David Perea Pérez,Michael E O&#x;Dwyer
David Perea Pérez
Enable CAR T cell immunotherapy in glioblastoma by modifying its microenvironment via oncolytic adenovirus encoding bispecific T cell engager [0.03%]
利用溶瘤腺病毒编码双特异性T细胞衔接器改变胶质母细胞瘤微环境以增强CAR-T细胞免疫疗法的功效
Moon Jung Choi,Eui Young So,Bedia Akosman et al.
Moon Jung Choi et al.
Recent clinical trials show that CAR T cell therapies can initially blunt tumor growth in patients with glioblastoma (GBM). However, therapeutic efficacy remains limited by the immunosuppressive tumor microenvironment and restricted immune ...
Protecting the sugar coat on anti-tumor T cells to conceal destruction by tumor microenvironmental landmines [0.03%]
保护抗肿瘤T细胞的“盔甲”以抵御肿瘤微环境中的“地雷”攻击
Lee Seng Lau,Charles J Dimitroff
Lee Seng Lau
NeuroD1 gene therapy inhibits glioma growth and extends life span through in vivo reprogramming approach [0.03%]
神经D1基因治疗通过体内重编程序抑制胶质瘤生长并延长寿命
Yuchen Chen,Zuoyu Jiang,Sen Jin et al.
Yuchen Chen et al.
Glioblastoma(GBM), a highly aggressive primary brain tumor characterized by rapid progression, frequent recurrence, and limited clinical options, remains one of the most lethal central nervous system malignancies. Here, we report a gene the...