Natural killer cell immunotherapy for pancreatic cancer: Release the brakes [0.03%]
胰腺癌的自然杀伤细胞免疫治疗：释放“刹车”
Stacey N Lee,Jeanette E Boudreau
Stacey N Lee
Neural stem cell delivery of oncolytic CRAd-S-pk7 immunotherapy for stage 3 ovarian cancer: Dose-regimen studies [0.03%]
针对III期卵巢癌的神经干细胞递送溶瘤CRAd-S-pk7免疫治疗：剂量方案研究
Rachael Mooney,Gary Ngai,Gurmeet Kaur et al.
Rachael Mooney et al.
Ovarian cancer (OVCA) is an aggressive and often recurrent malignancy with limited long-term responses to standard chemotherapy. To address the urgent need for novel, targeted therapies, we evaluated the efficacy of a tumor-tropic neural st...
An integrative transcriptomic analysis for prognosis and tumor microenvironment in HBV/HCV-associated hepatocellular carcinoma [0.03%]
HBV/HCV相关肝细胞癌的整合转录组分析用于预后和肿瘤微环境研究
Fahimeh Safarnezhad Tameshkel,Niloufar Sadat Kalaki,Elham Karimi et al.
Fahimeh Safarnezhad Tameshkel et al.
Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality worldwide; molecular biomarkers that reflect hepatitis B virus (HBV)/hepatitis C virus (HCV)-associated tumor biology and predict prognosis or therapeutic vulnerabilities...
Distinct bile mycobiome signature identifies fungal peptide panel predictive for gallbladder carcinoma [0.03%]
独特的胆汁真菌谱型可识别预测胆囊癌的真菌肽图谱
Sanju Yadav,Nupur Sharma,Manisha Yadav et al.
Sanju Yadav et al.
Carcinoma of the gallbladder (CAGB) carries a poor prognosis. While alterations in the bile microbiome and lipidome have been linked to CAGB development, the contribution of the fungal microbiome remains unexplored. We investigated fungal m...
Reprogramming the immune suppressive tumor microenvironment in glioma enhances the efficacy of immune-mediated gene therapy [0.03%]
重新编程胶质瘤免疫抑制性肿瘤微环境可增强免疫介导基因治疗的疗效
Brandon L McClellan,Jorge A Peña Agudelo,Anzar A Mujeeb et al.
Brandon L McClellan et al.
Gliomas account for ∼80% of primary malignant brain tumors. Many CNS WHO grade 2-3 and some grade 4 gliomas harbor mutant isocitrate dehydrogenase 1 (mIDH1), which causes a gain-of-function mutation (IDH1 R132H) leading to the production o...
Engineering precision oncology: Targeting tumors and immune cells with lentiviral vectors [0.03%]
工程精准肿瘤学：用慢病毒载体靶向肿瘤和免疫细胞
Julia Rossi,Chiara Martinello,Riccardo Sorrentino et al.
Julia Rossi et al.
Lentiviral vectors (LVs) are emerging as versatile tools for the efficient and stable delivery of therapeutic genes. Although VSV-G-pseudotyped LVs remain the standard for ex vivo genetic engineering, their broad tropism and serum sensitivi...
Nanobody-engineered CLL-1 CAR T cells: A strategy for safer targeting in acute myeloid leukemia [0.03%]
CLL-1纳米抗体工程CAR-T细胞：急性髓系白血病安全靶向的新策略
Chakrapani Tripathi,Frank Luh,Yun Yen
Chakrapani Tripathi
Stem cell-directed targeted chemotherapy primes drug-resistant metastatic ovarian tumors for elimination by natural killer cells [0.03%]
基于干细胞定向的化疗可诱导卵巢癌转移瘤对自然杀伤细胞介导的免疫攻击变得敏感
Mohammad Massumi,Geng Li,Hajar Owji et al.
Mohammad Massumi et al.
Cancer stem-like cells (CSCs) drive ovarian cancer metastasis, therapeutic resistance, and relapse. This study aimed to develop a combination therapeutic strategy capable of eliminating both rapidly proliferating ovarian cancer cells and dr...
Fibulin-4 expressed in metastatic breast cancer is a target of peptide-based imaging probes and experimental therapeutics [0.03%]
转移性乳腺癌中表达的纤维蛋白原样蛋白4是肽基分子影像探针和实验治疗的目标
Alexes C Daquinag,Sukhen C Ghosh,Solmaz AghaAmiri et al.
Alexes C Daquinag et al.
There is a lack of approaches to detect and kill metastatic cells. As an agent for metastasis targeting, a cyclic peptide BLMP6 has been previously characterized. As a step toward translation, we designed AZDye555-labeled BLMP6 and demonstr...