Rapidly evolved PD-1 for enhance receptor and checkpoint inhibitor in immunotherapy [0.03%]
快速进化PD-1受体和检查点抑制剂用于免疫治疗
Xiaowei Mei,Xuelong Li,Yasong Wu et al.
Xiaowei Mei et al.
PD-1 is a crucial molecule indispensable for maintaining immune homeostasis. Disrupting the interaction between PD-1 and its ligands can significantly enhance the immune system's ability to combat tumors. By integrating the PD-1 ligand-bind...
Comparison of the in vivo biodistributions of αvβ6-binding agents for PET imaging applications [0.03%]
αvβ6结合剂在PET显像中的体内分布比较研究
Emma A Swift,Stephen J Paisey,Toby J Phesse et al.
Emma A Swift et al.
Expression of the αvβ6 integrin is upregulated on multiple solid epithelial tumors while this integrin is largely absent on the healthy human epithelium. In the present study, we sought to compare the in vivo biodistributions of three αv...
Jia Li,Yanhong Shi
Jia Li
Disarming CAR-Tregs with a clinical-stage natural product to supercharge CAR-T therapy [0.03%]
利用临床阶段的天然产物使CAR-Tregs失活以增强CAR-T疗法
Bowen Li,Haoran Xu,Wenjun Zhang et al.
Bowen Li et al.
Multi-omics dissection of R-loop dynamics in tumorigenesis: From transcription-replication conflict to therapeutic targets [0.03%]
转录与复制冲突介导的R环动态调控肿瘤发生：从多组学解析到治疗靶标发现
Yu Zhang,Nuorong Xiong,Yueyang Song et al.
Yu Zhang et al.
R-loops, three-stranded nucleic acid structures comprising an RNA-DNA hybrid and a displaced single-stranded DNA strand, play context-dependent roles in cancer-serving essential physiological functions while also driving tumorigenesis when ...
Retraction Notice to: Therapeutic potential of IBP as an autophagy inducer for treating lung cancer via blocking PAK1/Akt/mTOR signaling [0.03%]
撤销通知:IBP通过抑制PAK1/Akt/mTOR信号诱导自噬治疗肺癌的潜力
Huimin Bu,Shirui Tan,Bo Yuan et al.
Huimin Bu et al.
[This retracts the article DOI: 10.1016/j.omto.2020.10.014.]. © 2026 The Author(s).
Integrating multi-omics analysis and machine learning to refine molecular subtypes and prognostic assessment of lower-grade glioma [0.03%]
整合多组学分析和机器学习以精炼低级别胶质瘤的分子亚型和预后评估
Qian Jiang,Ai-Yu Yang,Guan-Ling Mo et al.
Qian Jiang et al.
Lower-grade glioma (LGG) is a highly heterogeneous disease, making accurate prognosis prediction and the development of precise, personalized treatment plans for patients challenging. The multi-omics data from patients with LGG were analyze...
Enhancing immunotherapy efficacy of hepatocellular carcinoma by inhibiting the key antioxidant factor Nrf2 [0.03%]
通过抑制关键抗氧化因素Nrf2增强肝细胞癌免疫治疗疗效
Yan Zhu,Maoxuan Liu,Hang Fai Kwok et al.
Yan Zhu et al.
Kaoutar Bentayebi,Sara Louati,Keittisak Suwan et al.
Kaoutar Bentayebi et al.
Medulloblastoma accounts for approximately 20% of all pediatric brain tumors. Standard treatment typically involves a multimodal approach including surgery, radiation therapy, and chemotherapy. Despite advances in molecular classification a...
Nicotinamide mononucleotide enhances anti-tumor effect by resetting macrophages toward the inflammatory M1-like phenotype [0.03%]
烟酰胺单核苷酸通过重塑巨噬细胞的M1表型增强抗肿瘤作用
Haoran Xu,Marcus Chun Tao Wan,Chelsey Chi Ching Wong et al.
Haoran Xu et al.
Nicotinamide mononucleotide (NMN) supplementation has shown clinical benefits by regulating metabolic activities in the energy production process. Its protective effect and underlying immune regulatory mechanisms against tumor progression a...