Combined radiation and Listeria immunotherapy induces cytotoxic immunity that correlates with improved outcome in dogs with osteosarcoma [0.03%]
放疗联合Listeria免疫疗法诱导细胞毒性免疫并改善骨肉瘤犬的预后
Nicola J Mason,Josephine Gnanandarajah,Martha MaloneyHuss et al.
Nicola J Mason et al.
Ionizing radiation acts synergistically with immunotherapy by inducing immunogenic cell death and modulating the tumor microenvironment, promoting anti-tumor immune responses. In this pilot study, the safety and effectiveness of palliative ...
Innovative photodynamic therapy using rose bengal for the treatment of human melanoma [0.03%]
玫瑰精创新光动力疗法治疗人类黑色素瘤研究
Marie Boileau,Anthony Lefebvre,Smail Marhfor et al.
Marie Boileau et al.
Rose Bengal (RB), a xanthene dye with established antitumor and immunomodulatory properties, is a cytotoxic molecule evaluated in human melanoma through phase 2 clinical trials. RB demonstrates intrinsic therapeutic activity; however, its c...
SIRPα ablated iPSC-derived macrophages resist hypophagia and enhance mAb-dependent and CAR-mediated cytotoxicity of solid tumors [0.03%]
SIRPα敲除的诱导多能干细胞来源的小胶质细胞具有抵抗摄食减少和增强单克隆抗体依赖性和CAR介导的实体瘤细胞毒性的能力
Portia R Smith,Md Ehsanul Kabir,Jue Zhang et al.
Portia R Smith et al.
The SIRPα-CD47 "don't eat me" checkpoint axis plays a critical role in shaping antitumor activities of macrophages within the tumor microenvironment (TME). However, targeting this axis with anti-CD47 antibodies to enhance antitumor respons...
Mevalonate pathway activation in Ewing sarcoma reveals a 3D-specific synergy between statins and BCL-xL inhibition [0.03%]
异戊二酸途径在尤因肉瘤中的活化揭示了他汀类药物和BCL-xL抑制剂在三维培养中的协同作用
Branka Radic-Sarikas,Marica Markovic,Martha Magdalena Zylka et al.
Branka Radic-Sarikas et al.
Bone sarcomas are rare and aggressive pediatric cancers with limited progress in targeted therapy development, partly due to the poor physiological relevance of conventional two-dimensional (2D) culture systems used for preclinical testing....
Cancer frenemy pathways: Inducing immunogenic cell death by exploiting apoptosis-interferon antagonism with oncolytic viruses [0.03%]
癌症宿敌途径：利用溶瘤病毒诱导免疫原性细胞死亡并发挥凋亡-干扰素拮抗作用
Vladimir Bozhdansky,Eran Bacharach,Marcelo Ehrlich
Vladimir Bozhdansky
mRNA-LNP vaccine providing antigen and co-stimulation in the tumor microenvironment enhances CAR T cell function (CART-Vac) [0.03%]
在肿瘤微环境中提供抗原和协同刺激的mRNA-LNP疫苗增强CAR-T细胞功能(CART-Vac)
Ikumi Nakashima,Shoji Saito,Jingbo Zhao et al.
Ikumi Nakashima et al.
Despite advances in multimodal therapies, outcomes for pediatric patients with relapsed or refractory cancers remain poor. Chimeric antigen receptor (CAR) T cell therapy has demonstrated limited efficacy in solid tumors due to the immunosup...
CpG 1018 augments mRNA vaccine-induced anti-tumor immunity by potentiating CD8+ T cell responses [0.03%]
CpG 1018通过增强CD8+T细胞反应来增强mRNA疫苗诱导的抗肿瘤免疫
Yibo Li,Jayachandra Reddy Nakkala,Labone Akter et al.
Yibo Li et al.
Personalized neoantigen mRNA vaccines showed good efficacy in treating metastatic melanoma, pancreatic cancer, and breast cancer in early phase clinical trials. Strategies are needed to further enhance neoantigen mRNA vaccine-induced anti-t...
Fit cells, fertile ground: Immunometabolic programming and bone marrow niche support in durable CAR T cell response in leukemia [0.03%]
适配细胞，沃土丰饶：CAR-T 细胞在白血病中持久应答的免疫代谢编程和骨髓生态位支持
Xiuli Wang,Lior Goldberg
Xiuli Wang
Differentiation-inducing triiodothyronine enhances chemotherapy and suppresses post-treatment tumor regrowth in medulloblastoma [0.03%]
三碘甲状腺原氨酸分化诱导剂可增强髓母细胞瘤化疗并抑制术后肿瘤再生长
Yijun Yang,Rebecca Ronsley,Lindsay Kilburn et al.
Yijun Yang et al.
Medulloblastoma (MB), the most common malignant pediatric brain tumor, is treated with intensive multimodal regimens that cause substantial long-term toxicity and fail to prevent recurrence in up to 30% of patients. We investigated triiodot...
Optimizing CAR T cell therapy in pancreatic cancer through clinically actionable combinations [0.03%]
通过临床可操作的组合优化胰腺癌的CAR-T细胞治疗
Giulia Escobar,Marcela V Maus
Giulia Escobar