Oncolytic HSV-1 expressing FLT3L kills melanoma, glioblastoma, and pancreatic cancer cells in vitro and induces immunogenic cell death [0.03%]
表达FLT3L的溶瘤HSV-1杀死体外黑色素瘤、胶质母细胞瘤和胰腺癌细胞并诱导免疫原性细胞死亡
Sandra Tuyaerts,Xenia Geeraerts,Alberto Reale et al.
Sandra Tuyaerts et al.
Oncolytic viruses (OVs) are promising anti-cancer agents designed to induce cancer cell death while simultaneously stimulating immune responses through encoded transgenes. FMS-like tyrosine kinase 3 ligand (FLT3L), a critical cytokine in de...
Effective gene immunotherapy for melanoma utilizing an advanced in vivo electrotransfer system [0.03%]
一种新型体内电转染系统在黑色素瘤基因免疫治疗中的应用研究
Loree C Heller,Julie S Singh,Jody C Synowiec et al.
Loree C Heller et al.
Interleukin-12 (IL-12) is a potent immune stimulator that induces the proliferation and activation of natural killer (NK) and T cells and the secretion of interferon (IFN)-γ. While IL-12 is an effective anti-cancer therapy, high concentrat...
Aurora kinase A drives non-canonical YAP1/TAZ crosstalk to sustain primary resistance to anti-EGFR therapies in colorectal cancer [0.03%]
aurora 同源物 a 驱动非canonical yap1/taz 交叉对话以维持对结直肠癌抗 egfr 疗法的主要抵抗性
Anxo Rio-Vilariño,Ana Garcia-Bautista,Aiora Cenigaonandia-Campillo et al.
Anxo Rio-Vilariño et al.
Anti-epidermal growth factor receptor (EGFR) therapies are the most recommended first-line treatment for RAS/RAF wild-type unresectable metastatic colorectal cancer (CRC) according to the European Society for Medical Oncology guidelines. Ho...
TREM-1 as a novel immunotherapeutic target to treat pancreatic ductal adenocarcinoma [0.03%]
靶向 Trem-1 作为治疗胰腺导管腺癌的新型免疫疗法
Lina Gross,Ivanina Mutisheva,Hanne Hillen et al.
Lina Gross et al.
Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is highly aggressive with limited curative options, primarily surgical resection. However, only about 20% of the tumors are resectable at diagnosis. Immunot...
CHEK1 is a synthetic lethal interactor of FBXO7 in colonic epithelial cells [0.03%]
CHK1是结肠上皮细胞中FBXO7的合成致死性互作蛋白
Tooba Razi,Ally C Farrell,Rubi Campos Gudiño et al.
Tooba Razi et al.
Colorectal cancer (CRC) remains a leading cause of cancer mortality worldwide, with chromosome instability (CIN) present in approximately 85% of cases and associated with poor prognosis. Reduced expression of FBXO7, a component of the SKP1-...
Syncytial death mediated by oncolytic rVSV-NDV dynamically activates immunogenic apoptosis and necroptosis in human lung cancer cells [0.03%]
溶瘤rVSV-NDV介导的合胞体死亡动态激活人肺癌细胞免疫性凋亡和坏死性凋亡
Fabian Kortum,Nina Hartmann,Alexander Bryan et al.
Fabian Kortum et al.
Recent work has indicated that oncolytic virotherapy leads to immunogenic cell death (ICD) as an important mechanism of action; however, the underlying cell death pathways leading to ICD have been less explored. Our previous data demonstrat...
Targeting MDM2 homodimer and heterodimer disruption with DRx-098D in TP53 wild-type and mutant cancer cells [0.03%]
靶向TP53野生型和突变型癌细胞中MDM2同源二聚体和异源二聚体的抑制剂DRx-098D
Sean F Cooke,Thomas A Wright,Gillian Lappin et al.
Sean F Cooke et al.
Novel pharmacological strategies capable of inhibiting pro-oncogenic MDM2 beyond its p53-dependent functions represent increasingly attractive therapeutic strategies to treat solid and hematological cancers that are dependent upon MDM2/MDMX...
Mechanotransduction-related ferroptosis: Enhancing boron neutron capture therapy efficacy in glioblastoma using a spheroid model [0.03%]
与机械转导相关的铁死亡：使用类球体模型增强硼中子捕获疗法在胶质母细胞瘤中的疗效
Lin-Sheng Yu,Jia-Jun Liu,Ming-Hung Yang et al.
Lin-Sheng Yu et al.
Boron neutron capture therapy (BNCT) shows potential for the treatment of glioblastoma, the most aggressive form of primary brain tumor. Recently, ferroptosis, a cell death triggered by phospholipid peroxidation, has been identified as an i...
Oncolytic vaccinia virus expressing non-secreted decoy-resistant IL-18 mutein elicits potent antitumor effects with enhanced safety [0.03%]
表达不出分泌的IL-18 mutein的溶瘤痘苗病毒具有增强的安全性并能显著提高抗肿瘤效应
Junjie Ye,Lingjuan Chen,Sefali Patel et al.
Junjie Ye et al.
Cytokines are promising for cancer treatment but face challenges like short half-lives, high-dose requirements, and systemic toxicity. Oncolytic viruses provide an ideal platform to overcome these limitations by delivering cytokines directl...
Lei Zhang,Yanbin Zhu,Kunpeng Zheng et al.
Lei Zhang et al.
Oncolytic herpes simplex virus type 1 (HSV-1) directly targets and destroys tumor cells while selectively infecting surrounding tumor tissue and releasing progeny viruses to continue the attack. We engineered the replicative HSV-1 vector, i...