Complex genetic landscape in CLL: Clinical impact on patients' survival and insights into the altered molecular pathways [0.03%]
复杂遗传谱系在CLL中的临床影响及对患者生存和改变分子通路的见解
Carlo Caputo,Massimo Donadelli,Mariateresa Scupoli et al.
Carlo Caputo et al.
Chronic lymphocytic leukemia (CLL) is characterized by a remarkably complex landscape. We performed a molecular characterization of liquid biopsies from 137 leukemia samples and 10 healthy subjects. Almost all patients express single-nucleo...
Targeted nanoencapsulation of tunicamycin reduces toxicity while improving its therapeutic effectiveness in pancreatic cancer cells [0.03%]
靶向纳米封装肿瘤霉素减少其毒性并提高其在胰腺癌细胞中的治疗效果
Debasmita Dutta,Sunil P Upadhyay,Archana De et al.
Debasmita Dutta et al.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the leading sources of cancer mortality worldwide. An initial response to chemotherapy, such as gemcitabine (GEM) alone or in combination with other chemotherapies, is often followed by...
CircSPINT2 confers sensitivity to osimertinib via hsa-miR-1296-3p/RBP1 axis and inhibits NSCLC progression [0.03%]
Circular RNA CircSPINT2 通过 hsa-miR-1296-3p/RBP1 轴介导对奥希替尼的敏感性并抑制非小细胞肺癌进展
Nalini Devi Verusingam,Aliaksandr A Yarmishyn,Min-Long Tsai et al.
Nalini Devi Verusingam et al.
Lung adenocarcinoma (LUAD) is the most common type of lung cancer. Prolonged treatment of LUAD with 1st/2nd generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) promotes the emergence of secondary EGFR T790M mu...
Targeting glioblastoma using oncolytic viruses delivered by human pluripotent stem cell-derived neural progenitor cells [0.03%]
人多能干细胞衍生的神经前体细胞递送肿瘤选择性病毒治疗胶质母细胞瘤
Jianfei Chao,Qi Cui,Peng Ye et al.
Jianfei Chao et al.
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor that has no cure. Oncolytic virotherapy is emerging as an effective approach to target cancer cells. Here, we show that the CF17 oncolytic virus, either del...
Epigenetic co-regulator HCF-1 promotes lung cancer via O-GlcNAcylation-dependent pathways [0.03%]
表观遗传共调节因子HCF-1通过O-GlcNAc酰化促进肺癌的发展
Priyanka P Srivastava,Abhilash Dasari,Saran Kumar et al.
Priyanka P Srivastava et al.
The rise in the incidences of lung cancer currently poses a global health challenge, making it crucial to understand the underlying molecular and cellular mechanisms. Host cell factor-1 (HCF-1), a conserved epigenetic transcriptional co-reg...
Targeting BCMA in multiple myeloma: A comprehensive review of immunotherapeutic strategies and clinical outcomes [0.03%]
靶向BCMA治疗多发性骨髓瘤：免疫治疗策略及临床疗效的全面回顾
Chi Ho Chan,Xin Yang,Minchuan Lyu et al.
Chi Ho Chan et al.
Multiple myeloma (MM) is the second most common hematologic malignancy and remains incurable, highlighting an urgent need for novel therapeutic strategies. B cell maturation antigen (BCMA), predominantly expressed on mature B lymphocytes, p...
Loss of tumor suppressor circRNA CircSPINT2 drives osimertinib resistance in lung adenocarcinoma [0.03%]
肿瘤抑制circRNA CircSPINT2的丢失驱动了肺腺癌患者对奥希替尼产生的耐药性
Rakesh Bhatia,Sanjib Chaudhary
Rakesh Bhatia
Targeting MITF as a tyrosine-kinase-inhibitor-independent strategy for treating GIST [0.03%]
靶向MITF作为治疗GIST的酪氨酸激酶抑制剂独立策略
Sai Fung Yeung,Qiqian Huang,Kaixi Liang et al.
Sai Fung Yeung et al.
Probing the metabolic regulator and candidate tumor suppressor ALDH1L1 as a target for non-small cell lung cancer gene therapy [0.03%]
醛醇脱氢酶1家族成员L1的代谢调节及抑癌作用在非小细胞肺癌基因治疗中的应用研究
Amira A Abdellatef,Blake R Rushing,Susan Sumner et al.
Amira A Abdellatef et al.
ALDH1L1, a major cytosolic folate enzyme and key regulator of one-carbon metabolism, is strongly and ubiquitously downregulated in lung adenocarcinomas (LUADs) and silenced in LUAD cell lines. Analysis of publicly available databases indica...
Perturbed CD81 in lung-cancer-derived extracellular vesicles modifies its function in cancer pathophysiology [0.03%]
肺癌来源的细胞外囊泡中的干扰CD81在癌症病理生理学中改变其功能
Anjugam Paramanantham,Siddharth Das,Rahmat Asfiya et al.
Anjugam Paramanantham et al.
Lung cancer (LC) remains a leading cause of cancer-related fatalities, necessitating an urgent need for potent treatment strategies. This study investigates the role of extracellular vesicle (EV) cargo: CD81 in lung cancer progression and i...