Identifying gene expression signatures of oncolytic virus response in patient-derived pancreatic ductal adenocarcinoma organoids [0.03%]
利用源自患者的胰腺导管腺癌器官芯片鉴定溶瘤病毒反应的基因表达标志物
Marco Huberts,Elham Aida Farshadi,Farzana Mohammad et al.
Marco Huberts et al.
Pancreatic ductal adenocarcinoma is among the deadliest cancers, with a poor prognosis. Viro-immunotherapy using oncolytic viruses represents a promising treatment. However, pancreatic ductal adenocarcinoma from different patients responds ...
Lentiviral-mediated panErbB CAR-T cell therapy against head and neck squamous cell carcinomas for patients with Fanconi anemia [0.03%]
用于范可尼贫血头颈鳞癌患者的泛ErbB嵌合抗原受体T细胞疗法
Andrea López,David Charbonnier,Paula Vela et al.
Andrea López et al.
Fanconi anemia (FA) is a DNA repair syndrome characterized by bone marrow failure and cancer predisposition, including acute myeloid leukemia and solid tumors such as head and neck squamous cell carcinoma (HNSCC). Due to the exacerbated tox...
Optimization of the VSV-G backbone for amino terminal fusion with nanobodies allowing its specific retargeting to HER2 receptors [0.03%]
优化VSV-G载体以实现与纳米抗体的氨基末端融合并使其能够特异性靶向HER2受体
Isoline Duquénois,Stéphanie Thébault,Sarah Johari et al.
Isoline Duquénois et al.
Vesicular stomatitis virus (VSV) is a promising oncolytic virus. Additionally, its glycoprotein G (VSV-G) is the most commonly used envelope glycoprotein to pseudotype lentiviral vectors for gene therapy. However, VSV receptors (low-density...
Advances in augmenting infiltration of active natural killer cells into pediatric and adult solid tumors [0.03%]
增强活性自然杀伤细胞向儿童和成人实体瘤浸润的研究进展
Shiori Eguchi,Wen Luo,Hongwen Zhu et al.
Shiori Eguchi et al.
Although adoptive natural killer cell therapies have been safe and somewhat effective in hematological malignancies, their performance in solid tumors is hindered by the solid tumor microenvironment, which impairs natural killer cell traffi...
Confronting cancer's complexity: Cell and gene therapies in an era of rising incidence [0.03%]
应对癌症的复杂性：发病率上升时代的细胞和基因疗法
Kristen Pate
Kristen Pate
CXCL10-induced chemotaxis of ex vivo-expanded natural killer cells combined with NKTR-255 enhances anti-tumor efficacy in osteosarcoma [0.03%]
CXCL10诱导的体外扩增的自然杀伤细胞化性结合NKTR-255提高骨肉瘤的抗肿瘤效应
Shiori Eguchi,Wen Luo,Hongwen Zhu et al.
Shiori Eguchi et al.
Osteosarcoma (OSA) has a dismal prognosis despite surgical resection and multiagent chemotherapy. While adoptive natural killer (NK) cell therapies have been successful in hematological malignancies, the application in solid tumors is chall...
Enhanced solid tumor cell targeting by a neoepitope-encoding oncolytic measles virus combined with CAR therapy [0.03%]
编码新表位的溶细胞麻疹病毒联合CAR疗法增强对实体瘤细胞靶向能力
Alexander Renner,Maximiliane S C Finkbeiner,Ferdinand V Haas et al.
Alexander Renner et al.
Despite the success of cell therapy in treating hematological malignancies, the treatment of solid tumors remains challenging due to the tumor microenvironment (TME) and a lack of suitable antigens. To address this, we investigated a putati...
HIF1A, BRG1, and p300 interaction confers paclitaxel-induced drug resistance by enabling the overexpression of ABCC genes [0.03%]
HIF1A、BRG1和p300的相互作用通过上调ABCC基因表达赋予紫杉醇诱导的耐药性
Karolina Gronkowska,Kinga Kołacz-Milewska,Sylwia Michlewska et al.
Karolina Gronkowska et al.
The development of resistance to paclitaxel (PTX), which is a vital anticancer drug treating breast and lung cancers, can cause treatment failure and limit further use of taxanes and similar drugs. As previously documented, PTX-induced irre...
Design, development, and evaluation of gene therapeutics specific to KSHV-associated diseases [0.03%]
针对KSHV相关疾病基因治疗药物的设计、开发及评估
Tomoki Inagaki,Jonna Magdallene Espera,Kang-Hsin Wang et al.
Tomoki Inagaki et al.
Kaposi sarcoma associated herpesvirus (KSHV) is the causative agent of Kaposi sarcoma (KS) and two human B cell lymphoproliferative diseases. KSHV-encoded latency-associated nuclear antigen (LANA) is expressed in KSHV-infected cancer cells....
Erratum: Ovatodiolide triggers ferroptosis in high-grade serous ovarian cancer through HMOX1 upregulation [0.03%]
Correction: 高级别浆液性卵巢癌卵叶素诱导铁死亡的新机制(HMOX1 启动上调)
Yew-Min Tzeng,Aye Aye Khine,Hsuan-Shun Huang et al.
Yew-Min Tzeng et al.
[This corrects the article DOI: 10.1016/j.omton.2025.201023.]. © 2025 The Author(s).
Published Erratum
Molecular therapy. Oncology. 2025 Sep 20;33(4):201059. DOI:10.1016/j.omton.2025.201059 2025