Development of potent Affitin-based bispecific NK cell engagers for the therapy of MSLN-expressing cancers [0.03%]
开发用于治疗MSLN阳性癌症的强力基于Affitin的双特异性NK细胞ENGAGE剂
Tina Briolay,Tacien Petithomme,Hermelyne Gravoueille et al.
Tina Briolay et al.
Well-characterized tumor-associated antigens (TAAs) represent targets of interest in many anticancer therapeutic strategies. Although the use of monoclonal antibodies has led this field for years, the development of smaller molecules, with ...
Using the iCasp9 suicide strategy to control the growth and function of genome-edited B cells with redirected antigen specificity [0.03%]
利用iCasp9自杀策略控制重定向抗原特异性的基因组编辑B细胞的生长和功能
Jenny Léonard,Marine Cahen,Anne-Laure Tanguy et al.
Jenny Léonard et al.
B cells could be effective immunotherapeutic "drug cells," but reports of genomic editing to redirect their specificity have not included safety strategies. To address the potential complications of cell therapy, there is a growing demand f...
PanERBB CAR T-cells: Shifting gears toward a cure for fanconi anemia head/neck cancers [0.03%]
泛ERBB CAR-T细胞：向范可尼贫血头颈部癌症治愈目标迈进
Constanze Wiek,Saskia Hüsken,Kathrin Scheckenbach et al.
Constanze Wiek et al.
Stephen L Trisno,Mark A Kay
Stephen L Trisno
A KRASG12V-targeted bispecific T cell engager promotes immunity against colorectal solid tumor [0.03%]
一种KRASG12V双特异性T细胞衔接剂促进结直肠实体瘤免疫治疗
Nhan Huynh,Thu-My Thi Nguyen,Ngoc Thi Bui et al.
Nhan Huynh et al.
Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations have been detected at high rates in various tumor types, making them one of the most commonly mutated oncogenes. Limited relevant binding pockets have rendered these mutants undrug...
Directed evolution generates an oncolytic Sindbis virus with enhanced tumor-killing capacity in osteosarcoma [0.03%]
定向进化生成了一种增强型肿瘤杀伤能力的骨肉瘤洋葱病毒
Kangyixin Sun,Qinghan Wang,Li Li et al.
Kangyixin Sun et al.
Osteosarcoma, a common cancer in adolescents, is characterized for its strong propensity for metastasis, which complicates treatment and results in a poor survival rate. Despite established therapies, the challenge remains to effectively ta...
Hehai Pan,Jessica B Foster,Kristopher R Bosse
Hehai Pan
Viral warriors: Unlocking the immune system's potential with oncolytic viruses in cancer immunotherapy [0.03%]
病毒勇士：溶瘤病毒在癌症免疫治疗中激活免疫系统潜力的作用
Reza Ghavimi,Leila Rahimian,Mohsen Mohammadi et al.
Reza Ghavimi et al.
Oncolytic viruses (OVs) represent an exciting avenue in tumor immunotherapy, harnessing the power of viruses to overcome resistance and enhance immune responses. OVs achieve this by selectively targeting and destroying tumor cells. This cel...
Pharmacological evaluation of 1-acetyl-β-carboline, a naturally occurring compound with anti-skin cancer potential [0.03%]
1-乙酰基-β-咔啉的药理学评价：一种具有潜在抗皮肤癌作用的天然化合物
Munseon Lee,Sun-Young Hwang,Kwanhwan Wi et al.
Munseon Lee et al.
The human microbiome comprises microbial communities that reside in the human body and contribute to host health through molecular mediators. Lactobacillus spp. are frequently used as probiotics to restore microbial balance, and L. gasseri ...