María Florencia Pignataro,Javier Santos
María Florencia Pignataro
Identification and evaluation of novel intergenic sites in the vaccinia virus genome for transgene insertion [0.03%]
痘病毒基因组中新转基因插入位点的鉴定和评价
Carmen Bueno-Merino,Ana Del Canizo,Miquel Conesa et al.
Carmen Bueno-Merino et al.
Vaccinia virus (VACV) is widely used as a vaccine and oncolytic vector due to its safety profile and its capacity to accommodate exogenous DNA. However, its compact genome offers limited loci for transgene insertion without disrupting funct...
Strategically engineering an oncolytic herpes simplex virus to improve systemic delivery [0.03%]
通过改良溶瘤HSV提高其静脉给药效果
Xinping Fu,Tomasz Benedyk,Shaun Xiaoliu Zhang
Xinping Fu
Oncolytic virotherapy (OV) has emerged as a promising cancer treatment strategy, utilizing viruses to selectively infect and destroy tumor cells while simultaneously stimulating anti-tumor immunity. OV has also been shown to modulate the tu...
Erratum: Survivin/BIRC5-derived peptide disrupts survivin dimerization and cell division and induces multifaceted anti-cancer effects [0.03%]
survivin/BIRC5衍生的肽打断survivin二聚体和细胞分裂并产生多效抗癌作用（刊误）
Manikandan Santhanam,Venkatadri Babu,Anna Shteinfer-Kuzmine et al.
Manikandan Santhanam et al.
[This corrects the article DOI: 10.1016/j.omton.2025.201123.]. © 2026 The Author(s).
Published Erratum
Molecular therapy. Oncology. 2026 Jan 30;34(1):201142. DOI:10.1016/j.omton.2026.201142 2026
Erratum: Efficiently targeting neuroblastoma with the combination of anti-ROR1 CAR NK cells and N-803 in vitro and in vivo in NB xenografts [0.03%]
correction: 用抗ROR1的CAR-NK细胞和N-803有效靶向神经母细胞瘤：体外与异种移植瘤体内实验结果
Yaya Chu,Gaurav Nayyar,Meijuan Tian et al.
Yaya Chu et al.
[This corrects the article DOI: 10.1016/j.omton.2024.200820.]. © 2025 The Author(s).
Published Erratum
Molecular therapy. Oncology. 2026 Jan 30;34(1):201112. DOI:10.1016/j.omton.2025.201112 2026
Sai Zhu,Ruiling Xu,Haodong Xu et al.
Sai Zhu et al.
Immunotherapy has revolutionized cancer treatment by harnessing the immune system against malignancies; however, traditional antibody-based therapies are hampered by high production costs, immunogenicity, and off-target effects. Aptamers-sh...
Current use of pre-clinical models for evaluation of human adenovirus-based cancer therapeutics [0.03%]
人腺病毒基癌症治疗的非临床模型的当前应用评估
David K Cole,Rahul C Khanolkar,James A Davies et al.
David K Cole et al.
Human adenoviruses (HAdVs) are enjoying a renaissance in interest for the development of cancer therapies following the approval of Adstiladrin (Ferring Pharmaceuticals) for the treatment of bladder cancer, strong phase 3 data from CG Oncol...
An attenuated coxsackievirus B5 mutant carrying VP1-N157K retains oncolytic potency against non-small cell lung cancer [0.03%]
含VP1-N157K的减毒柯萨奇病毒B5变异体对非小细胞肺癌仍具有溶瘤潜力
Lifang Song,Bopei Cui,Qiushuang Gao et al.
Lifang Song et al.
Oncolytic virus therapy is a rapidly developing cancer treatment method. The development of oncolytic viruses often involves genetic modifications, such as increased expression of foreign proteins for enhancing the antitumor capabilities an...
Pyrimidine-based compounds as promising anticancer agents targeting tumor cell senescence [0.03%]
具有靶向肿瘤细胞衰老的潜力的抗癌症药物嘧啶类化合物
Paula Carpintero-Fernández,M Montserrat Martínez,Alexander Carneiro-Figueira et al.
Paula Carpintero-Fernández et al.
The pyrimidine ring is an important structural motif present in numerous bioactive compounds, including those with antibacterial and antitumor activities. In this study, two novel 4,6-disubstituted-2-(4-morpholinyl) pyrimidines (P12 and P14...
A measles virus encoding a CD19/CD3 bispecific T cell engager shows enhanced preclinical anti-BCP-ALL efficacy without significant toxicity [0.03%]
一种编码靶向CD19和CD3的双特异性T细胞接头分子的麻疹病毒，在治疗B系前体急性淋巴细胞白血病时，显示出更佳的药效且没有明显毒性作用
Sabine Heinze,Giovanna L Stadler,Yonghui Zhang et al.
Sabine Heinze et al.
Children with high-risk B-cell precursor acute lymphoblastic leukemia (BCP-ALL) continue to face relapse and treatment resistance, emphasizing the urgent need for novel therapeutic strategies. In this study, we developed and characterized a...